Hydrolyzed Zinc Hyaluronate Powder — Cosmetic Grade Supplier
Hydrolyzed Zinc Hyaluronate (INCI: Hydrolyzed Zinc Hyaluronate, HA backbone CAS 9067-32-7, MW 10-50 kDa, Zinc 5.0-8.0%) — the bioactive zinc-hyaluronate complex for anti-acne, sebum regulation, wound healing, and anti-inflammatory skincare. A dual-action ingredient combining enzymatically hydrolyzed low-MW HA for deep skin penetration with complexed zinc ions for antimicrobial (P. acnes inhibition), 5-alpha-reductase sebum control, and anti-inflammatory soothing. Unlike standard sodium hyaluronate which provides hydration only, zinc hyaluronate delivers hydration PLUS active treatment — the functionally superior HA for acne-prone, oily, inflamed, or compromised skin. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Cosmetic-grade zinc hyaluronate manufacturer and bulk supplier — UPOR Biotech.
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Hydrolyzed Zinc Hyaluronate Powder (INCI: Hydrolyzed Zinc Hyaluronate, HA backbone CAS 9067-32-7, MW 10-50 kDa, Zinc Content 5.0-8.0%) is an advanced bioactive cosmetic ingredient that combines enzymatically hydrolyzed low-molecular-weight hyaluronic acid with complexed zinc ions in a stable, water-soluble powder. This dual-action material delivers the deep, multi-layer hydration of HA alongside the proven antimicrobial, anti-inflammatory, and sebum-regulating properties of zinc — making it a uniquely effective active for anti-acne formulations, oil-control treatments, and compromised skin repair. Zinc hyaluronate addresses a critical gap in cosmetic formulation: traditional sodium hyaluronate provides excellent hydration but no active treatment for acne or inflammation, while standalone zinc compounds (zinc PCA, zinc oxide, zinc sulfate) often lack the skin-conditioning and moisture-binding benefits formulators also need. The hydrolyzed low-MW form (10-50 kDa) ensures enhanced skin penetration compared to standard high-MW HA (1,500-2,000 kDa) — allowing both the HA hydration and zinc therapeutic components to reach target skin layers (epidermis-dermis junction and dermis) efficiently. The zinc ions are complexed to HA carboxylate (-COO⁻) groups via ionic bonding, providing a controlled-release zinc delivery system that maintains free Zn²⁺ concentration in the optimal therapeutic range (micromolar) without the astringency or irritation of high-concentration free zinc salts. Zinc’s mechanisms in skin: (1) Antimicrobial — Zn²⁺ inhibits P. acnes growth (MIC ~0.5-2 mM) via disruption of bacterial membrane potential and inhibition of lipase/protease virulence factors. (2) Sebum regulation — zinc is a recognized 5-alpha-reductase type I inhibitor (IC50 ~10-50 μM), reducing the conversion of testosterone to DHT in sebocytes and decreasing sebum production by 30-50% at clinically used concentrations. (3) Anti-inflammatory — Zn²⁺ suppresses NF-κB activation and reduces pro-inflammatory cytokines (IL-6, IL-8, TNF-α) in keratinocytes — directly addressing the inflammatory component of acne. (4) Wound healing — zinc promotes keratinocyte proliferation and migration (via Zn²⁺-dependent matrix metalloproteinase modulation), collagen synthesis, and angiogenesis. UPOR Biotech manufactures hydrolyzed zinc hyaluronate under c-GMP and ISO 9001:2015 with COSMOS natural certification, HALAL, and KOSHER.
As a specialized cosmetic-grade zinc hyaluronate manufacturer and bulk supplier, UPOR Biotech provides this bioactive HA-zinc complex for B2B cosmetic brands, contract manufacturers, and professional treatment line formulators worldwide. OEM formulations available. Free sample available for qualified B2B buyers.
Zinc Hyaluronate vs Standard Sodium Hyaluronate — Beyond Hydration
Standard sodium hyaluronate provides hydration only — essential but not sufficient for acne-prone, oily, or inflamed skin. Zinc hyaluronate delivers hydration PLUS active treatment: antimicrobial action against P. acnes (Zn²⁺ MIC ~0.5-2 mM), 5-alpha-reductase inhibition for sebum control (IC50 ~10-50 μM, 30-50% sebum reduction), anti-inflammatory NF-κB suppression for redness reduction, and wound healing promotion via keratinocyte migration and collagen synthesis. The hydrolyzed low-MW form (10-50 kDa) penetrates deeper than standard high-MW HA. For any formulation targeting problematic skin — anti-acne, oil-control, soothing, post-procedure repair — zinc hyaluronate is the functionally superior HA choice.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Hydrolyzed Zinc Hyaluronate Powder — Cosmetic Grade |
| INCI Name | Hydrolyzed Zinc Hyaluronate |
| HA Backbone CAS | 9067-32-7 (Sodium Hyaluronate); Zinc complex — CAS not assigned (metal-complexed HA derivative) |
| Molecular Weight | 10 – 50 kDa (hydrolyzed low-MW — GPC-MALLS verified; enables enhanced skin penetration) |
| Zinc Content — Critical Quality Attribute | 5.0 – 8.0% (ICP-OES verified; ionic bonding to HA carboxylate groups — controlled-release Zn²⁺ delivery) |
| Key Advantage | Dual-action bioactive HA: hydration (HA backbone) + antimicrobial/sebum-regulating/anti-inflammatory/wound healing (complexed Zn²⁺). Hydrolyzed low-MW for enhanced penetration. COSMOS certified. |
| Appearance | White to off-white powder; free-flowing |
| Purity (HPLC) | ≥98.0% total HA-zinc complex (HPLC-UV at 205 nm) |
| pH (0.1% w/v Solution, 25°C) | 5.0 – 6.5 (optimal for Zn²⁺ ion availability and formulation compatibility) |
| Zinc Ion Availability | Free Zn²⁺ concentration maintained at therapeutic micromolar levels via controlled release from HA carboxylate ionic complex — avoids astringency/irritation of free zinc salts |
| Solubility | Freely soluble in water; forms light, non-tacky solution (low-MW HA avoids the sticky residue of high-MW HA) |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals (Total) | ≤10 ppm |
| Elemental Impurities | Pb ≤2 ppm; As ≤1 ppm; Hg ≤1 ppm; Cd ≤1 ppm (ICH Q3D; including zinc-related heavy metal screening) |
| Microbial Limits | TAMC ≤100 CFU/g; TYMC ≤50 CFU/g (USP <61>); Pathogens — Negative (USP <62>) |
| Formulation Compatibility | Compatible with aqueous phase; pairs well with niacinamide, salicylic acid, centella asiatica, panthenol; avoid strong chelating agents (EDTA >0.1% may compete for Zn²⁺) |
| Optimal Formulation pH | 5.0 – 6.5 (maximizes Zn²⁺ availability; below pH 4.5 Zn²⁺ may fully dissociate from HA; above pH 7.0 Zn(OH)₂ precipitation risk) |
| Recommended Usage | 0.1 – 0.5% w/w in cosmetic formulations (effective at low concentration due to hydrolyzed form and zinc bioavailability) |
| Grade | Cosmetic Grade |
| Certifications | ISO 9001:2015, c-GMP (ICH Q7), FDA Facility Registration, HALAL, KOSHER, COSMOS Natural Certified, USP/EP compliant |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers with desiccant |
| Storage | 2-8°C recommended; tightly sealed; protect from moisture (hygroscopic) and light |
| Shelf Life | 3 years under recommended storage; MW, zinc content, and solubility re-verified at 3/6/12/24/36 months |
Key Benefits — Hydrolyzed Zinc Hyaluronate
Anti-Acne and Antimicrobial — P. acnes Inhibition
Complexed Zn²⁺ ions inhibit Propionibacterium acnes growth (MIC ~0.5-2 mM) via disruption of bacterial membrane potential and inhibition of lipase/protease virulence factors. Combined with HA’s non-comedogenic hydration, targets acne at its root while keeping skin balanced.
Anti-AcneSebum Regulation — 5-Alpha-Reductase Inhibition
Zinc is a recognized 5-alpha-reductase type I inhibitor (IC50 ~10-50 μM), reducing testosterone→DHT conversion in sebocytes and decreasing sebum production by 30-50%. Delivers oil-control alongside lightweight HA hydration — matte, balanced results without dryness.
Oil ControlAnti-Inflammatory and Soothing — NF-κB Suppression
Zn²⁺ suppresses NF-κB activation and reduces pro-inflammatory cytokines (IL-6, IL-8, TNF-α) in keratinocytes. HA supports barrier function. Dual anti-inflammatory pathways calm irritated, red, and inflamed skin — ideal for post-acne redness and sensitive skin.
CalmingWound Healing and Skin Repair — Zn²⁺ + HA Synergy
Zinc promotes keratinocyte proliferation/migration, collagen synthesis, and angiogenesis. HA supports tissue regeneration and moist healing environment. Together, a powerful repair complex for compromised, post-procedure, or blemish-damaged skin.
RepairApplications
Anti-Acne Serums and Treatment Formulations
Star active in treatment serums targeting active acne, breakouts, and blemish-prone skin. Combines antimicrobial action against P. acnes with non-comedogenic, non-sticky HA hydration at 0.1-0.5%. Pairs with niacinamide and salicylic acid.
Oil-Control and Sebum-Balancing Products
Key ingredient in sebum-regulating moisturizers, mattifying gels, and purifying toners. 5-alpha-reductase inhibition reduces shine at the source while HA maintains essential skin hydration — no over-drying.
Soothing and Calming Care — Sensitive and Redness-Prone Skin
Ideal for sensitive skin serums, redness-reducing ampoules, and post-acne recovery creams. Dual anti-inflammatory pathways (Zn²⁺ NF-κB + HA barrier support) calm inflammation while supporting barrier repair.
Post-Procedure Repair — Peels, Microneedling, Laser
Supports skin recovery after chemical peels, microneedling, and laser treatments. Dual wound healing action (Zn²⁺ keratinocyte migration + HA tissue regeneration) accelerates recovery and comfort post-procedure.
Professional Treatment Lines — Clinic-Grade Formulations
Used in clinic-grade formulations and professional aesthetic protocols where active treatment of acne, inflammation, or compromised skin is the primary goal. COSMOS certified for natural/professional positioning.
Functional Cosmeceuticals — Bridge Cosmetics and Dermatology
Core active in cosmeceutical products delivering clinically relevant zinc benefits (antimicrobial, sebum control, anti-inflammatory) in elegant, consumer-friendly cosmetic vehicles with HA hydration and skin feel.
Molecular Weight Comparison — HA Grades
| Grade | Molecular Weight | Primary Function | Skin Penetration |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, thickening, surface hydration | Surface only |
| Medium MW | 1,000-1,500 kDa | Moisturizing, moderate thickening | Upper epidermis |
| Low MW | 400-1,000 kDa | Deep hydration, anti-wrinkle | Deeper epidermis |
| Extra Low MW | 100-400 kDa | Deep skin penetration, firming | Epidermis-dermis junction |
| Super Low MW | 20-50 kDa | Transdermal delivery, plumping | Dermis |
| Oligo HA | 7-10 kDa | Cellular signaling, wound healing | Deep dermis |
| Zinc Hyaluronate (this product) | 10-50 kDa + Zn 5.0-8.0% | Anti-acne, sebum regulation, wound healing, anti-inflammatory | Epidermis-Dermis |
| HA Low pH (<50 kDa) | <50 kDa | Acidic delivery, exfoliation-compatible hydration | Epidermis-Dermis |
Frequently Asked Questions
Hydrolyzed zinc hyaluronate is a bioactive HA-zinc complex combining enzymatically hydrolyzed low-MW hyaluronic acid (10-50 kDa) with complexed zinc ions (5.0-8.0%). The hydrolysis process reduces HA molecular weight for enhanced skin penetration (reaching epidermis-dermis junction vs surface-only for high-MW HA), while the zinc component — ionically bonded to HA carboxylate (-COO⁻) groups for controlled release — delivers four therapeutic mechanisms: antimicrobial activity against P. acnes (MIC ~0.5-2 mM Zn²⁺), 5-alpha-reductase inhibition for sebum control (IC50 ~10-50 μM, 30-50% sebum reduction), anti-inflammatory NF-κB suppression (reduced IL-6, IL-8, TNF-α), and wound healing promotion (keratinocyte migration, collagen synthesis). This dual-action ingredient simultaneously hydrates and actively treats — a gap that plain sodium hyaluronate cannot fill.
Hydrolyzed zinc hyaluronate (0.1-0.5%) is primarily used in anti-acne serums and treatments (targeting active P. acnes while providing non-comedogenic hydration), oil-control and sebum-balancing formulations (5-alpha-reductase inhibition reduces shine without over-drying), soothing post-procedure care (dual anti-inflammatory pathways calm redness and irritation), wound healing and skin repair creams (Zn²⁺ keratinocyte migration + HA tissue regeneration), anti-inflammatory masks and ampoules (for sensitive/rosacea-prone skin), and purifying toners for blemish-prone skin. Its unique zinc-HA combination is especially valuable for oily, acne-prone, or compromised skin where hydration and antimicrobial activity are needed simultaneously.
While both deliver HA’s hydration benefits, zinc hyaluronate adds the therapeutic properties of controlled-release zinc: antimicrobial against P. acnes (standard HA has none), 5-alpha-reductase inhibition for sebum control (standard HA has none), anti-inflammatory NF-κB suppression (standard HA has weak anti-inflammatory activity via CD44 only), and wound healing promotion (standard HA supports via moist healing; zinc HA adds active keratinocyte migration and collagen synthesis). The hydrolyzed low-MW form (10-50 kDa) penetrates deeper than standard high-MW HA (1,500-2,000 kDa — surface only). Choose zinc hyaluronate when formulating for acne-prone, oily, or inflamed skin — conditions where plain sodium hyaluronate provides hydration but no active treatment benefit. For general hydration/moisturization without skin concerns, standard HA may be sufficient and more cost-effective.
ISO 9001:2015, c-GMP (ICH Q7), FDA-registered drug establishment, HALAL, KOSHER, and COSMOS Natural Certified. All products meet USP and EP standards. Every shipment includes COA (with zinc content by ICP-OES, MW by GPC-MALLS, purity by HPLC), MSDS, TSE/BSE statement (fermentation-derived — animal-free), stability data, and complete lot traceability.
0.1-0.5% w/w in cosmetic formulations. Effective at low concentrations due to the hydrolyzed low-MW form (enhanced skin penetration) and zinc-enhanced bioavailability (controlled release from HA carboxylate ionic complex maintains therapeutic free Zn²⁺ at micromolar levels). Water-soluble — easily incorporated into aqueous phases of serums, gels, ampoules, and emulsion systems. For anti-acne: pairs with niacinamide (4%), salicylic acid (0.5-2%), and centella asiatica. Formulate at pH 5.0-6.5 for optimal zinc ion availability — below pH 4.5 Zn²⁺ fully dissociates (potential astringency), above pH 7.0 risk of Zn(OH)₂ precipitation. Avoid EDTA >0.1% which may compete for Zn²⁺.