Sodium Hyaluronate Powder — Extra Low Molecular Weight 100-400 kDa Supplier
Sodium Hyaluronate Extra Low Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 100-400 kDa) — the DEJ-targeted deep-delivery HA for structural firming, collagen support, and visible skin restructuring. At 100-400 kDa, the polymer chains are small enough (hydrodynamic radius ~10-20 nm) to traverse the full thickness of the epidermis and reach the epidermis-dermis junction (DEJ) — the critical anchoring zone where type IV/VII collagen and laminin-332 form the hemidesmosome basement membrane complex connecting epidermal basal keratinocytes to the papillary dermis. This is where fibroblasts reside and where collagen type I/III and elastin fibers provide skin’s structural integrity. Extra low MW HA at the DEJ: (1) delivers firming hydration to the dermal-epidermal anchoring system, (2) activates fibroblast CD44/RHAMM receptors stimulating collagen synthesis and dermal matrix maintenance, (3) supports the basement membrane HA-rich pericellular matrix essential for keratinocyte-fibroblast crosstalk. Higher MW grades (≥400 kDa) are physically excluded from the DEJ — only the 100-400 kDa range achieves this depth of targeted delivery. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Extra low MW HA manufacturer and bulk supplier — UPOR Biotech.
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Sodium Hyaluronate Extra Low Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 100-400 kDa) is an advanced deep-penetrating HA grade engineered for delivery to the epidermis-dermis junction (DEJ) — the structural foundation of skin firmness. At 100-400 kDa (hydrodynamic radius ~10-20 nm), the polymer chains traverse the full epidermal thickness: stratum corneum (10-20 μm) → stratum granulosum → stratum spinosum → stratum basale → through the basement membrane into the papillary dermis where type I/III collagen, elastin, and fibroblasts reside. This is the deepest target reached by any non-hydrolyzed HA grade — higher MW grades (400-2,000 kDa, hydrodynamic radius ≥20 nm) are physically excluded before reaching the DEJ. At the DEJ, extra low MW HA activates fibroblast CD44 and RHAMM receptors, stimulating: (1) collagen type I and III synthesis via TGF-β/Smad2/3 pathway, (2) elastin and fibrillin-1 production for elastic fiber assembly, (3) HAS1/HAS2 upregulation increasing endogenous HA production by fibroblasts. These mechanisms translate to clinically observed improved skin firmness, elasticity, dermal density, and reduced fine lines. Controlled enzymatic depolymerization of high MW HA using hyaluronidase (HYAL1) produces a narrow, consistent MW distribution (PDI <1.5) verified by GPC-MALLS for every batch — ensuring reproducible DEJ-targeted penetration and biological activity. UPOR Biotech manufactures under c-GMP and ISO 9001:2015 with COSMOS certification.
Extra Low MW HA — DEJ-Targeted Delivery for Structural Anti-Aging
High MW HA stays on the surface (stratum corneum only). Low MW HA reaches the deeper epidermis. Extra low MW HA (100-400 kDa) goes beyond — to the epidermis-dermis junction (DEJ), the critical anchoring zone where type IV/VII collagen, laminin-332, and hemidesmosomes form the basement membrane complex. At this depth, HA activates fibroblast CD44/RHAMR receptors → stimulates collagen I/III synthesis, elastin production, and endogenous HA upregulation. For formulations targeting visible firming, dermal restructuring, and professional-grade anti-aging, this targeted DEJ delivery is the mechanistic foundation that separates true structural rejuvenation from surface-level hydration.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder — Extra Low Molecular Weight |
| CAS Number | 9067-32-7 |
| MW Range | 100 – 400 kDa (GPC-MALLS; controlled enzymatic depolymerization; PDI <1.5) |
| Key Advantage | DEJ-targeted delivery (hydrodynamic radius ~10-20 nm). Fibroblast CD44/RHAMR activation. Collagen I/III + elastin synthesis. Furthest non-hydrolyzed HA penetration. |
| Appearance | White to off-white powder or granules |
| Purity (HPLC) | ≥99.0% |
| pH (0.1% w/v) | 6.0 – 7.5 |
| Bulk Density | 0.20 – 0.40 g/mL |
| Solubility | Soluble in water; low-viscosity solution — ideal for serums and ampoules |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals | ≤10 ppm |
| Recommended Usage | 0.1 – 0.3% w/w; combine with high MW HA for multi-level system |
| Grade | Cosmetic Grade / Food Grade |
| Certifications | ISO 9001:2015, c-GMP, FDA, HALAL, KOSHER, COSMOS, USP/EP |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers |
| Storage | 15-25°C; dry, dark; tightly sealed; shelf life 2-3 years |
Key Benefits — Extra Low MW HA
DEJ-Targeted Delivery — Reaches Basement Membrane Zone
Hydrodynamic radius ~10-20 nm enables full epidermal traversal to the DEJ — the basement membrane anchoring zone. Only non-hydrolyzed HA grade achieving this depth. Delivers HA directly to the collagen-elastin-fibroblast structural foundation.
DEJ TargetVisible Firming — Collagen I/III and Elastin Synthesis
Fibroblast CD44/RHAMR activation at the papillary dermis stimulates TGF-β/Smad2/3-mediated collagen I/III synthesis and elastin/fibrillin-1 production. Clinically demonstrated improved skin firmness, elasticity, and dermal density.
FirmingEndogenous HA Upregulation — HAS1/HAS2 Stimulation
Extra low MW HA fragments (100-400 kDa) are the optimal size range for CD44-mediated HAS1/HAS2 upregulation in fibroblasts — stimulating the skin’s own HA production for sustained, self-amplifying hydration beyond the applied dose.
Pro-CollagenConsistent MW Distribution — Enzymatic Depolymerization
Controlled hyaluronidase (HYAL1) depolymerization produces narrow, consistent MW distribution (PDI <1.5) verified by GPC-MALLS. Ensures reproducible DEJ penetration and biological activity batch-to-batch.
c-GMP CertifiedApplications
Professional Anti-Aging Treatments — DEJ-Level Results
Core active in professional-grade anti-aging at 0.1-0.3%. DEJ-targeted delivery addresses skin laxity, loss of firmness, and fine lines at the structural level for clinically meaningful results.
Firming Serums and Lifting Ampoules
Low viscosity at effective concentrations enables elegant, fast-absorbing firming serums. Combine with high MW HA for surface protection + DEJ restructuring in a single product.
Advanced Eye Treatments — Periocular DEJ Firming
Optimal MW for the thin periocular skin. Penetrates to firm crow’s feet and under-eye laxity without heavy residue or milia risk. Ideal for concentrated eye serums at 0.1-0.2%.
Medical Cosmetics and Post-Procedure Care
Meets medical cosmetic quality requirements. c-GMP manufactured with full traceability. Supports basement membrane repair and fibroblast activation during post-procedure recovery.
Neck and Jawline Firming — Thin-Skin Structural Care
Targeted DEJ-level treatment for neck/décolleté sagging. Addresses the structural causes in areas with thinner epidermis and fewer sebaceous glands for visible contouring results.
Premium Nutraceuticals — Bioavailable Oral HA
Food-grade extra low MW HA for beauty-from-within supplements. Enhanced absorption supports systemic skin hydration, joint health, and dermal matrix maintenance.
MW Comparison — HA Grades
| Grade | MW | Primary Function | Penetration |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, surface hydration | Surface only |
| Low MW | 400-1,000 kDa | Deep hydration, anti-wrinkle | Deeper epidermis |
| Extra Low MW (this product) | 100-400 kDa | DEJ-targeted firming, collagen support | Epidermis-dermis junction |
| Super Low MW | 20-50 kDa | Transdermal delivery, plumping | Dermis |
| Oligo HA | 7-10 kDa | Cellular signaling, wound healing | Deep dermis |
Frequently Asked Questions
Extra low MW HA (100-400 kDa) is a DEJ-targeted deep-penetrating grade for professional anti-aging treatments, firming serums, advanced eye care, and medical cosmetics. Its hydrodynamic radius (~10-20 nm) enables traversal of the full epidermis to reach the DEJ — the basement membrane anchoring zone where collagen/elastin fibers connect to basal keratinocytes. At this depth, it activates fibroblast CD44/RHAMR receptors stimulating collagen synthesis, elastin production, and endogenous HA upregulation for structural anti-aging.
To the epidermis-dermis junction (DEJ) — significantly deeper than high MW (surface only), medium MW (upper epidermis), and low MW (deeper epidermis). This is the furthest penetration achieved by any non-hydrolyzed HA grade. The DEJ is the critical anchoring zone — the structural foundation of skin firmness where collagen and elastin fibers connect to the epidermis via hemidesmosome basement membrane complexes.
Yes. At the DEJ and upper papillary dermis, extra low MW HA (100-400 kDa) activates fibroblast CD44/RHAMR receptors, stimulating TGF-β/Smad2/3-mediated collagen type I/III synthesis, elastin/fibrillin-1 production, and HAS1/HAS2-mediated endogenous HA upregulation. This multi-pathway fibroblast activation translates to clinically observed improved firmness, elasticity, dermal density, and reduced fine lines. Many formulators pair extra low MW HA with copper peptides or Matrixyl for synergistic collagen-boosting.
ISO 9001:2015, c-GMP, FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP/EP. Controlled enzymatic depolymerization (HYAL1) produces narrow, consistent MW distribution (PDI <1.5, GPC-MALLS verified). Full documentation: COA (MW, PDI, purity), MSDS, TSE/BSE, stability data, lot traceability.
0.1-0.3% w/w in serums, ampoules, and lightweight deep-penetration formulations. Produces low-viscosity solutions ideal for leave-on anti-aging products. Combine with high MW HA (surface film protection) for multi-level anti-aging: surface hydration + DEJ structural firming. Add to water phase below 40°C to preserve molecular integrity.