Sodium Hyaluronate Powder — Super Low Molecular Weight 20-50 K Da
Cosmetic & Food Grade. The deepest-penetrating HA grade — reaches the dermis for transdermal plumping, endogenous HA synthesis stimulation, and advanced cellular-level anti-aging. ISO, c-GMP, FDA, HALAL, KOSHER, COSMOS certified.
Request a QuoteProduct Overview
Sodium Hyaluronate Super Low Molecular Weight (20-50 K Da) represents the pinnacle of transdermal HA delivery. At this oligomeric molecular weight, hyaluronate molecules are small enough to penetrate through the entire skin — epidermis, DEJ, and into the dermis — delivering HA directly to fibroblasts. Here, it performs two critical functions: immediate deep dermal plumping through direct water binding in the dermal matrix, and stimulation of endogenous HA synthesis via CD44 receptor signaling on fibroblasts. This dual action — delivering HA while triggering the skin’s own HA production — sets super low MW HA apart as the most advanced, scientifically sophisticated HA grade.
UPOR Biotech supplies this product with complete regulatory documentation under c-GMP conditions with full lot traceability.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder (Super Low Molecular Weight) |
| CAS Number | 9067-32-7 |
| Molecular Weight | 20 – 50 K Da |
| Appearance | White to off-white fine powder |
| Purity (HPLC) | ≥99.0% |
| pH (0.1% solution) | 6.0 – 7.5 |
| Loss on Drying | ≤10.0% |
| Heavy Metals | ≤10 ppm |
| Grade | Cosmetic Grade & Food Grade |
| Certifications | ISO 9001, c-GMP, FDA, HALAL, KOSHER, COSMOS |
| Standards | USP, EP compliant |
| Packaging | 1 kg/bag, 5 kg/bag, 25 kg/drum |
Key Benefits
Full Transdermal Delivery
Penetrates through the entire skin to reach the dermis — the deepest delivery of any HA grade. Delivers hydration directly to the skin’s structural foundation.
Dermis-LevelHA Synthesis Stimulation
Oligomeric HA fragments (20-50 K Da) are recognized by fibroblast CD44 receptors, signaling cells to increase endogenous HA production — for longer-lasting, self-sustaining results.
Pro-HA SignalDeep Dermal Plumping
Binds water directly within the dermal extracellular matrix, providing visible, measurable skin plumping from the deepest layers outward. Results build over 4-8 weeks.
Visible ResultsHighest Bioavailability
At 20-50 K Da, this HA grade has the highest oral bioavailability. Rapidly absorbed in the GI tract for systemic distribution to skin and joints.
Max AbsorptionApplications
Dermal Plumping Serums
Premium deep-acting serums for visible skin volume restoration and plumping from the dermis level.
Mesotherapy Solutions
Injectable-grade HA for professional mesotherapy and skin booster treatments in aesthetic medicine.
High-Absorption Supplements
Maximum-bioavailability oral HA for premium beauty-from-within nutraceuticals and joint health.
Professional Ampoules
Clinic-grade concentrated ampoules for intensive skin renewal and deep hydration courses.
FAQ
At 20-50 K Da, it is the only HA grade small enough to penetrate into the dermis — all higher MW grades stop in the epidermis. Once in the dermis, it does two things: directly plumps the dermal matrix with water, and signals fibroblasts to produce more HA. This dual action — immediate + long-term — is unique to this MW range.
Yes. Published research shows HA fragments in the 20-50 K Da range bind to fibroblast CD44 receptors and trigger intracellular signaling cascades that upregulate HA synthase (HAS2) expression. This means the skin produces more of its own HA — a self-sustaining anti-aging effect.
0.05-0.3% — less is needed due to high bioactivity and deep delivery. Typically 0.1% for serums. Instantly dispersible; cold-process compatible.
Super low MW HA has excellent thermal and pH stability. However, due to very short chain length, it does not provide viscosity. Combine with higher MW HA grades if formulation viscosity is required.