Sodium Hyaluronate Powder — High Molecular Weight 1,500-2,000 kDa Supplier
Sodium Hyaluronate High Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 1,500-2,000 kDa) — the maximum film-forming, thickening, and surface hydration grade of HA. At 1.5-2.0 million Daltons, the exceptionally long polymer chains (hydrodynamic radius ~50-200 nm) are physically excluded from the stratum corneum intercellular spaces (~50-100 nm) — remaining entirely on the skin surface to form a breathable, viscoelastic protective film that delivers immediate barrier protection, reduces transepidermal water loss (TEWL), and provides intense surface moisturization. High viscosity building at low concentrations (0.1-0.5% w/w) adds elegant, rich texture and sensorial body to creams, gels, and serums. The foundational HA grade — combine with lower MW HA for multi-level hydration: surface film protection + deep anti-aging delivery. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. High MW HA manufacturer and bulk supplier — UPOR Biotech.
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Sodium Hyaluronate High Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 1,500-2,000 kDa) is the flagship HA grade — the maximum molecular weight standard sodium hyaluronate commercially available. At 1.5-2.0 million Daltons, the exceptionally long polymer chains (~3,750-5,000 disaccharide units per chain) form an entangled viscoelastic network at the skin surface, creating a breathable, flexible film that delivers immediate barrier protection, TEWL reduction, and intense surface moisturization. The large hydrodynamic radius (~50-200 nm) physically exceeds the stratum corneum intercellular space width (~50-100 nm), ensuring complete surface retention — zero penetration into viable epidermis. This makes high MW HA the ideal surface-level humectant: it provides maximum film-forming, water-binding (~1,000× its weight), and viscosity building (0.1-0.5% w/w produces rich, elegant texture), functioning as both active moisturizer and natural-derived thickener/texturizer. The foundational HA grade for creams, gels, serums, sheet masks, and all cosmetic formats requiring protective surface film formation. For comprehensive multi-level hydration, combine high MW HA (surface film protection) with low MW HA (deep epidermal anti-wrinkle delivery).
High MW HA — Maximum Surface Film-Forming Protection
High MW HA (1,500-2,000 kDa) stays entirely on the skin surface — its large hydrodynamic radius (~50-200 nm) exceeds the SC intercellular space (~50-100 nm), physically preventing penetration. This is its defining functional characteristic: maximum film-forming barrier protection with zero epidermal penetration. Combine with lower MW HA grades for comprehensive multi-level hydration: high MW = surface film + TEWL reduction; low MW = deep epidermal anti-wrinkle delivery. The complete HA hydration architecture.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder — High Molecular Weight |
| CAS Number | 9067-32-7 |
| MW Range | 1,500 – 2,000 kDa (GPC-MALLS; highest standard commercial grade) |
| Key Advantage | Maximum film-forming and thickening. Breathable surface barrier protection. TEWL reduction. Rich, elegant texture builder. Zero epidermal penetration — purely surface-active. |
| Appearance | White to off-white powder or fibrous aggregate; hygroscopic |
| Purity (HPLC) | ≥99.0% |
| pH (0.1% w/v) | 6.0 – 7.5 |
| Intrinsic Viscosity | 2.5 – 4.5 m³/kg (EP) |
| Solubility | Soluble in water; forms viscous gel at ≥0.3% (hydrates in 2-4 hours with gentle stirring) |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals | ≤10 ppm |
| Recommended Usage | 0.1 – 0.5% w/w (0.1% light film; 0.3-0.5% rich texture + significant viscosity) |
| Grade | Cosmetic Grade / Food Grade |
| Certifications | ISO 9001:2015, c-GMP, FDA, HALAL, KOSHER, COSMOS, USP/EP |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers with desiccant |
| Storage | 15-25°C; dry, dark; tightly sealed; shelf life 2-3 years |
Key Benefits — High MW HA
Maximum Film-Forming — Breathable Surface Barrier
Forms a viscoelastic, breathable protective film on the skin surface. Reduces TEWL while allowing normal skin respiration (WVTR ~80-90% of uncovered skin). Immediate barrier protection and surface moisturization.
Film-FormingRich Texture Builder — Natural-Derived Thickener
At 0.1-0.5% w/w, builds elegant, rich viscosity without synthetic thickeners. Functions as both active moisturizer and natural texturizer — dual functionality in a single ingredient.
Texture BuilderIntense Surface Hydration — 1,000× Water Binding
Binds ~1,000× its weight in water at the skin surface. Delivers immediate, intense surface moisturization — the classic HA hydrating mechanism consumers recognize and love.
Intense HydrationCertified Quality — Cosmetic and Food Grade
c-GMP (ICH Q7), USP/EP compliant, COSMOS Natural Certified, HALAL, KOSHER. Full documentation: COA, MSDS, TSE/BSE, stability data, lot traceability. The trusted, flagship HA grade.
c-GMP CertifiedApplications
Rich Creams and Balms — Maximum Texture and Protection
Core thickener and film-former at 0.3-0.5%. Delivers rich, luxurious texture and protective surface barrier for dry skin, night creams, and intensive moisturizers.
Hydrating Serums — Surface Film + Deep Hydration Synergy
At 0.1-0.3%, combined with low MW HA for multi-level: high MW surface film protection + low MW deep anti-aging. The gold standard HA serum blend.
Sheet Masks — Occluded Surface Hydration
Ideal for sheet mask essences at 0.1-0.3%. The occluded mask environment maximizes high MW HA surface film hydration and TEWL reduction during 15-20 minute wear.
Gel Formulations — Clear, Elegant Viscosity
Produces clear, elegant gels at 0.3-0.5%. Natural-derived thickener replacing synthetic carbomer/acrylate polymers for clean-label gel products.
Body Care — All-Over Surface Protection
Excellent for body lotions and hand creams at 0.1-0.3%. Provides all-day surface hydration and protective film for large-area application.
Dietary Supplements — Joint Health
Food-grade high MW HA for joint health capsules and nutraceuticals. Supports synovial fluid viscoelasticity — the original HA supplement application.
MW Comparison — HA Grades
| Grade | MW | Primary Function | Penetration |
|---|---|---|---|
| High MW (this product) | 1,500-2,000 kDa | Max film-forming, thickening, surface hydration | Surface only |
| Medium MW | 1,000-1,500 kDa | Balanced moisturizing, moderate thickening | Upper epidermis |
| Low MW | 400-1,000 kDa | Deep hydration, anti-wrinkle | Deeper epidermis |
| Oligo HA | 7-10 kDa | Cellular signaling, wound healing | Deep dermis |
Frequently Asked Questions
High MW HA (1,500-2,000 kDa) is the maximum film-forming and thickening grade. Its large hydrodynamic radius (~50-200 nm) exceeds SC intercellular spaces — remaining entirely on the surface to form a breathable protective film that reduces TEWL and delivers intense surface hydration. Used in rich creams, gels, sheet masks, and any formulation requiring barrier protection and elegant texture.
High MW HA stays entirely on the surface — maximum film-forming but zero epidermal penetration. Lower MW grades progressively penetrate deeper for anti-wrinkle effects. The optimal strategy combines high MW (surface protection + TEWL reduction) with low MW (deep anti-aging delivery) for comprehensive multi-level hydration architecture.
ISO 9001:2015, c-GMP (ICH Q7), FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP/EP. Full documentation: COA, MSDS, TSE/BSE, stability data, complete lot traceability.
0.1-0.5% w/w. At 0.1% — light film-forming hydration. At 0.3-0.5% — rich, elegant texture with significant viscosity. Hydrates slowly (2-4 hours gentle stirring). Combine with low MW HA (0.1-0.3%) for multi-level: surface film + deep anti-aging. Add to water phase with moderate shear mixing.
15-25°C in a dry, dark place. Keep tightly sealed — HA is highly hygroscopic. Shelf life 2-3 years under proper storage. Once dissolved in water, use within 24-48 hours or add appropriate preservatives. Avoid high humidity and direct sunlight during handling.