Sodium Hyaluronate Powder — Extra Low Molecular Weight 100-400 K Da
Cosmetic & Food Grade. Deep-penetrating bioactive hyaluronate reaching the epidermis-dermis junction for advanced skin firming, restructuring, and extracellular matrix support. ISO, c-GMP, FDA, HALAL, KOSHER, COSMOS certified.
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Sodium Hyaluronate Extra Low Molecular Weight (100-400 K Da) bridges the gap between traditional low MW HA and ultra-low oligomeric HA. At this molecular weight, HA molecules are small enough to penetrate through the entire epidermis, reaching the dermal-epidermal junction (DEJ) — the structural interface where skin aging first manifests. At the DEJ, extra low MW HA supports collagen and elastin anchoring, stimulates CD44 receptor activity, and provides visible skin firming and restructuring benefits that go beyond hydration alone.
This grade is ideal for advanced firming serums, lifting treatments, and skin renewal formulations. In food applications, its high bioavailability makes it excellent for beauty-from-within nutraceuticals. UPOR Biotech supplies with full regulatory documentation (COA, MSDS, stability data).
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder (Extra Low Molecular Weight) |
| CAS Number | 9067-32-7 |
| Molecular Weight | 100 – 400 K Da |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥99.0% |
| pH (0.1% solution) | 6.0 – 7.5 |
| Loss on Drying | ≤10.0% |
| Heavy Metals | ≤10 ppm |
| Grade | Cosmetic Grade & Food Grade |
| Certifications | ISO 9001, c-GMP, FDA, HALAL, KOSHER, COSMOS |
| Standards | USP, EP compliant |
| Packaging | 1 kg/bag, 5 kg/bag, 25 kg/drum |
Key Benefits
DEJ-Targeted Delivery
Penetrates through the full epidermis to reach the dermal-epidermal junction — the critical interface for skin structural support, collagen anchoring, and visible firming effects.
DEJ PenetrationCD44 Receptor Activation
At this MW range, HA fragments are bioactive — they bind to CD44 receptors on fibroblasts, stimulating HA synthesis and ECM (extracellular matrix) component production for lasting skin restructuring.
BioactiveVisible Firming & Lifting
Provides measurable skin firming, improved elasticity, and visible lifting effects. Ideal for age-defying serums and professional-grade firming treatments.
Clinically VisibleExcellent Bioavailability
Superior absorption in oral applications. Fast-dissolving and easily incorporated into capsules, tablets, and powdered drink mixes for beauty-from-within supplements.
Oral GradeApplications
Firming Serums
Advanced lifting and firming serums targeting sagging and loss of skin elasticity. DEJ-level restructuring action.
Professional Ampoules
High-potency professional treatments for aesthetic clinics and medi-spas requiring visible, measurable results.
Age-Defying Creams
Premium anti-aging day and night creams combining deep restructuring with surface moisturization.
Beauty Nutraceuticals
High-bioavailability oral HA for skin health supplements. Absorbs efficiently for systemic distribution to skin.
FAQ
Extra low MW HA (100-400 K Da) penetrates to the dermal-epidermal junction (DEJ) — deeper than low MW HA (400-1,000 K Da) which stays in the epidermis. At the DEJ, it supports structural proteins (collagen, elastin) and activates CD44 receptors on fibroblasts for active skin restructuring, not just passive hydration.
Yes — at 100-400 K Da, it has excellent oral bioavailability and is widely used in beauty-from-within capsules, tablets, and drink mixes. Many beauty supplement brands prefer extra low MW HA for its balance of absorbability and bioactivity.
0.1-0.5% in cosmetic formulations. Because extra low MW HA has very low viscosity, it disperses instantly and can be cold-processed. For firming serums, 0.2-0.3% is the sweet spot.