Sodium Hyaluronate Powder — Medium Molecular Weight 1,000-1,500 kDa Supplier
Sodium Hyaluronate Medium Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 1,000-1,500 kDa) — the versatile mid-range HA for balanced film-forming, moisturizing, and upper-epidermis penetration. Occupies the sweet spot between high MW surface film-forming and low MW deep penetration: provides immediate surface hydration via a light breathable film while the partial epidermal penetration delivers sustained sub-surface moisturization. Moderate thickening yields a smooth, elegant, non-stringy texture at 0.3-0.8% — ideal for light creams, lotions, serums, BB creams, foundations, body care, and eye care. Also available as Food Grade for dietary supplements. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Medium MW HA manufacturer and bulk supplier — UPOR Biotech.
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Sodium Hyaluronate Medium Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 1,000-1,500 kDa) occupies the versatility sweet spot between high MW (1,500-2,000 kDa, surface film-forming only) and low MW (400-1,000 kDa, deep epidermal penetration) HA grades. At 1.0-1.5 million Daltons, the polymer chains are long enough to provide effective surface film-forming, moisture retention, and moderate viscosity building (0.3-0.8% w/w produces elegant, non-stringy texture), yet small enough to enable partial penetration into the upper epidermis (stratum corneum through stratum granulosum) via the intercellular lipid pathway — delivering sustained sub-surface hydration that pure surface-film HA grades cannot achieve. This dual-action performance — immediate surface moisturization via film-forming + extended sub-surface hydration via partial epidermal penetration — makes medium MW HA the most adaptable single HA grade. It can serve as a standalone humectant in formulations where balanced performance is preferred over extreme specialization, or as the central component in multi-MW HA blends (with high MW for added surface film and low MW for deeper penetration). The moderate viscosity and smooth sensory profile (no stringiness or tackiness characteristic of high MW HA at equivalent concentrations) make it particularly well-suited for light-textured formulations — serums, essences, lotions, BB/CC creams — where consumer-preferred rapid absorption and silky after-feel are critical. In food and nutraceutical applications, medium MW HA is used as a premium dietary supplement ingredient supporting joint health (synovial fluid viscoelasticity) and beauty-from-within (skin hydration from oral supplementation). UPOR Biotech manufactures under c-GMP and ISO 9001:2015 with COSMOS natural certification and full regulatory documentation.
As a specialized HA manufacturer and bulk supplier, UPOR Biotech provides medium MW sodium hyaluronate for B2B cosmetic brands, contract manufacturers, and nutraceutical companies. OEM formulations available. Free sample for qualified B2B buyers.
Medium MW HA — The Versatile All-Rounder
High MW HA (1,500-2,000 kDa) is a heavy surface film-former — excellent for rich creams but limited to stratum corneum hydration only. Low MW HA (400-1,000 kDa) penetrates deep into the epidermis for anti-aging — ideal for serums but provides minimal surface film. Medium MW HA (1,000-1,500 kDa) bridges both worlds: enough chain length for effective surface film-forming and moisture retention, plus sufficient chain flexibility for partial upper-epidermis penetration delivering sustained sub-surface hydration. It is the most adaptable HA grade — a single-ingredient solution for light creams, lotions, essences, BB creams, and all-purpose moisturizers where balanced, versatile performance matters more than extreme specialization at either end of the MW spectrum.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder — Medium Molecular Weight |
| INCI Name | Sodium Hyaluronate |
| CAS Number | 9067-32-7 |
| Molecular Weight Range | 1,000 – 1,500 kDa (GPC-MALLS verified) |
| Key Advantage | Balanced dual-action HA: surface film-forming + upper-epidermis penetration. Smooth, non-stringy texture. Versatile standalone or blend component. Cosmetic and Food Grade. |
| Appearance | White to off-white powder or granules; hygroscopic |
| Purity (HPLC-UV 205 nm) | ≥99.0% |
| pH (0.1% w/v Solution, 25°C) | 6.0 – 7.5 |
| Glucuronic Acid Content | 42.0 – 48.0% |
| Intrinsic Viscosity | 1.5 – 3.0 m³/kg (EP compliant) |
| Bulk Density | 0.25 – 0.45 g/mL |
| Solubility | Soluble in water; forms moderately viscous solution at ≥0.5% w/v (hydrates in 1-3 hours with gentle stirring at 25°C) |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals (Total) | ≤10 ppm |
| Microbial Limits | USP <61>/<62> compliant |
| Recommended Usage — Cosmetic | 0.3 – 0.8% w/w (0.3% light moisturization; 0.5-0.8% texture enhancement and balanced hydration) |
| Grade | Cosmetic Grade / Food Grade |
| Certifications | ISO 9001:2015, c-GMP, FDA Facility Registration, HALAL, KOSHER, COSMOS Natural Certified, USP/EP compliant |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers with desiccant |
| Storage | 15-25°C; dry, dark place; tightly sealed (hygroscopic); avoid high humidity and direct sunlight |
| Shelf Life | 2-3 years under proper storage; once dissolved use within 24-48 hours or add preservatives |
Key Benefits — Medium MW Sodium Hyaluronate
Balanced Dual-Action Performance
Occupies the optimal middle ground: surface film-forming for immediate moisturization + partial upper-epidermis penetration for sustained sub-surface hydration. A true dual-action humectant — versatile standalone or central component in multi-MW HA blends.
Balanced MWSmooth, Elegant Texture — Moderate Thickening
At 0.3-0.8% w/w, delivers smooth, non-stringy viscosity without the heavy gel character of high MW HA. Ideal for light creams, lotions, and serums where rapid absorption and silky after-feel are consumer priorities.
Smooth TextureExtended Hydration — Surface + Sub-Surface
The mid-range MW enables partial intercellular lipid pathway penetration into the upper epidermis (SC through stratum granulosum) while retaining enough surface film for lasting moisturization — dual-level hydration from a single HA grade.
Dual ActionCertified Quality — Cosmetic and Food Grade
c-GMP (ICH Q7) manufacturing, USP/EP compliant, COSMOS Natural Certified, HALAL, KOSHER. Full documentation: COA, MSDS, TSE/BSE statement, stability data, lot traceability. Suitable for cosmetic and dietary supplement applications.
c-GMP CertifiedApplications
Light Creams and Lotions — Balanced Moisturization
Ideal mid-range thickener and moisturizer for fluid creams, body lotions, and daily moisturizers at 0.3-0.8%. Silky, non-greasy finish with smooth spreading and quick absorption.
Hydrating Serums and Essences — Fast-Absorbing
Lightweight, fast-absorbing texture perfect for water-based and emulsion serums. Delivers balanced surface and sub-surface hydration without the heaviness of high MW HA.
BB Creams and Foundations — Skin Feel Enhancement
Moderate viscosity and pigment dispersion aid in color cosmetics. Maintains natural, skin-like finish while providing moisturization. Compatible with silicone and water-based formulations.
Body Care and After-Sun Products — All-Over Hydration
Excellent for body lotions, hand creams, and after-sun products. Smooth spreading, quick absorption without surface residue — ideal for large-area application formats.
Dietary Supplements — Joint Health and Beauty-from-Within
Food-grade HA for joint health capsules, beauty-from-within nutraceuticals, and liquid supplement formulations. Supports synovial fluid viscoelasticity and skin hydration from oral supplementation.
Eye Care — Gentle Periocular Hydration
Lightweight, non-heavy moisturization for eye creams and serums. The moderate MW ensures effective hydration without dragging or heaviness around the delicate periocular area.
Molecular Weight Comparison — HA Grades
| Grade | MW | Primary Function | Penetration |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, thickening, surface hydration | Surface only |
| Medium MW (this product) | 1,000-1,500 kDa | Balanced moisturizing, moderate thickening | Upper epidermis |
| Low MW | 400-1,000 kDa | Deep hydration, anti-wrinkle | Deeper epidermis |
| Extra Low MW | 100-400 kDa | Deep penetration, firming | Epidermis-dermis junction |
| Oligo HA | 7-10 kDa | Cellular signaling, wound healing | Deep dermis |
Frequently Asked Questions
Medium MW HA (1,000-1,500 kDa) is a versatile all-rounder for light creams, lotions, serums, BB creams, foundations, body care, and eye care. It provides balanced dual-action: moderate surface film-forming and thickening + upper-epidermis penetration for extended sub-surface hydration. In food applications, used as a dietary supplement for joint health and beauty-from-within.
Medium MW bridges both worlds. High MW (1,500-2,000 kDa) stays on the surface — best for rich creams needing heavy film-forming. Low MW (400-1,000 kDa) penetrates deeper for anti-wrinkle benefits — best for serums. Medium MW offers enough surface presence for moisturization plus partial epidermal penetration for sustained hydration. Many formulators use medium MW as standalone or blend all three MWs for comprehensive multi-level hydration.
ISO 9001:2015, c-GMP (ICH Q7), FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP and EP. Every shipment: COA, MSDS, TSE/BSE statement, stability data, complete lot traceability.
0.3-0.8% w/w in cosmetic formulations. At 0.3% — light moisturization with minimal viscosity impact. At 0.5-0.8% — noticeable texture enhancement and balanced hydration. Hydrates more readily than high MW HA (1-3 hours full hydration with gentle stirring). Compatible with most cosmetic ingredients.
15-25°C in a dry, dark place. Keep tightly sealed — sodium hyaluronate is hygroscopic. Shelf life 2-3 years under proper storage. Once dissolved in water, use within 24-48 hours or add appropriate preservatives. Avoid high humidity and direct sunlight.