Sodium Hyaluronate Powder — Super Low Molecular Weight 20-50 kDa Supplier
Sodium Hyaluronate Super Low Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 20-50 kDa) — the ultra-penetrating HA for transdermal delivery to the dermis. At 20-50 kDa (hydrodynamic radius ~5-8 nm), the polymer chains are small enough to traverse the full epidermal thickness — stratum corneum → viable epidermis → basement membrane → into the papillary and reticular dermis — reaching the same tissue compartment targeted by injectable HA fillers. This is the only topical HA grade achieving dermal-level delivery (oligo HA at 7-10 kDa also reaches deep dermis but functions primarily via receptor-mediated signaling rather than physical volumization). At the dermis, super low MW HA: (1) provides intense water-binding and physical plumping of the dermal extracellular matrix (glycosaminoglycan-hydrated ground substance), (2) activates fibroblast CD44/RHAMR → HAS1/HAS2 upregulation for sustained endogenous HA production, and (3) supports collagen-elastin matrix hydration. The 20-50 kDa range is specifically optimized — smaller than 20 kDa (oligo HA) primarily triggers signaling cascades without significant physical water-binding capacity; larger than 50 kDa is progressively excluded from the dermis. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Super low MW HA manufacturer and bulk supplier — UPOR Biotech.
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Sodium Hyaluronate Super Low Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 20-50 kDa) is the ultra-penetrating, dermis-targeted HA grade — the smallest MW among standard commercial sodium hyaluronate grades (excluding oligo HA at 7-10 kDa). With a hydrodynamic radius of ~5-8 nm, these HA chains traverse the full epidermal barrier: through the tortuous intercellular lipid pathway of the stratum corneum (intercellular space ~50-100 nm width) → viable epidermis (stratum granulosum, spinosum, basale) → across the basement membrane (hemidesmosome complex, ~50-100 nm thickness) → into the papillary and reticular dermis — the same tissue layer targeted by intradermal HA filler injections (though fillers provide bulk volume via crosslinked depots while topical super low MW HA provides diffuse ECM hydration). This grade uniquely combines: (1) physical dermal water-binding and plumping — the 20-50 kDa chains retain sufficient length for meaningful water retention capacity (~500-1,000× weight in water binding) within the glycosaminoglycan-hydrated ground substance of the dermal ECM, creating visible volume enhancement; (2) fibroblast CD44/RHAMR receptor activation — stimulating HAS1/HAS2-mediated endogenous HA production for sustained, self-amplifying dermal hydration (auto-induction); and (3) collagen-elastin matrix hydration support — maintaining optimal water content of the collagen fibril network for mechanical resilience. The 20-50 kDa MW range is the optimal therapeutic window: below 20 kDa (oligo HA, 7-10 kDa) transitions to primarily receptor-mediated signaling and angiogenic/inflammatory modulation without significant physical water-binding; above 50 kDa is progressively excluded from the dermis due to hydrodynamic radius exceeding basement membrane porosity. UPOR Biotech produces super low MW HA via controlled hyaluronidase (HYAL1) enzymatic depolymerization of high MW HA, yielding a narrow, reproducible MW distribution (PDI <1.5, GPC-MALLS verified). Manufactured under c-GMP and ISO 9001:2015 with COSMOS certification.
Super Low MW HA — Transdermal Delivery to the Dermis
Most HA grades work on the surface (high MW, 1,500-2,000 kDa) or upper skin layers (low MW, 400-1,000 kDa). Super low MW HA (20-50 kDa) is fundamentally different — its hydrodynamic radius (~5-8 nm) is small enough to traverse the full epidermal thickness, cross the basement membrane, and reach the papillary and reticular dermis — the same tissue compartment as injectable HA fillers. The result is deep dermal hydration, visible skin plumping, and genuine dermal matrix rejuvenation from a non-invasive topical application — the closest alternative to injectable HA treatments. For formulations targeting visible volume enhancement, deep wrinkle improvement, or professional-grade anti-aging at the dermal level, this MW grade is the mechanistic foundation that makes transdermal HA delivery possible.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder — Super Low Molecular Weight |
| CAS Number | 9067-32-7 |
| MW Range | 20 – 50 kDa (GPC-MALLS; controlled HYAL1 depolymerization; PDI <1.5) |
| Key Advantage | Dermis-targeted transdermal delivery (hydrodynamic radius ~5-8 nm). Physical ECM water-binding + fibroblast CD44/RHAMR activation. Closest topical to injectable HA. |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥99.0% |
| pH (0.1% w/v) | 5.0 – 7.0 |
| Bulk Density | 0.20 – 0.40 g/mL |
| Solubility | Freely soluble; low-viscosity solution — ideal for serums and ampoules |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals | ≤10 ppm |
| Recommended Usage | 0.05 – 0.2% w/w; effective at very low concentrations due to high bioavailability |
| Grade | Cosmetic Grade |
| Certifications | ISO 9001:2015, c-GMP, FDA, HALAL, KOSHER, COSMOS, USP/EP |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers |
| Storage | 15-25°C; dry, dark; tightly sealed; shelf life 2-3 years |
Key Benefits — Super Low MW HA
True Transdermal Delivery — Reaches the Dermis
Hydrodynamic radius ~5-8 nm enables full epidermal traversal + basement membrane crossing into the papillary/reticular dermis — the only topical HA grade achieving dermal-level delivery with meaningful water-binding capacity. Reaches the same tissue layer as injectable HA fillers.
TransdermalIntense Skin Plumping — Dermal ECM Hydration
Delivers ~500-1,000× water-binding capacity directly to the dermal ECM glycosaminoglycan-hydrated ground substance. Produces visible, measurable skin volume enhancement from within — the physical plumping mechanism that makes this the closest topical to injectable HA.
Volume EffectFibroblast HAS1/HAS2 Activation — Sustained Endogenous HA
CD44/RHAMR-mediated fibroblast stimulation upregulates HAS1/HAS2 — the skin’s own HA production enzymes. Creates a sustained, self-amplifying dermal hydration cycle beyond the applied dose. Auto-induction mechanism for prolonged anti-aging benefit.
Dermal RepairPrecise MW Control — HYAL1 Enzymatic Depolymerization
Controlled hyaluronidase (HYAL1) depolymerization yields narrow, consistent 20-50 kDa distribution (PDI <1.5, GPC-MALLS verified). Ensures reproducible dermal penetration and biological activity — critical for transdermal claims substantiation.
c-GMP CertifiedApplications
Premium Plumping Serums — Visible Volume Enhancement
Star active in high-end plumping and volumizing serums at 0.05-0.2%. Dermal ECM water-binding delivers visible skin fullness and deep hydration — physical plumping from within.
Needle-Free Alternatives — Topical Filler Alternative
The closest topical to injectable HA. Ideal for brands marketing non-invasive plumping solutions and at-home dermal care. Transdermal delivery reaches the same tissue layer as fillers via non-invasive application.
Lip Volumizing Products — Dermal Lip Plumping
Key ingredient in lip plumping glosses, balms, and serums. Deep dermal hydration delivers visible lip volume enhancement through tissue hydration — needle-free lip plumping mechanism.
Professional Clinic Treatments — Mesotherapy and Protocols
Used in clinic-grade topical formulations, mesotherapy cocktails, and professional aesthetic protocols requiring dermal-level HA delivery. c-GMP manufactured for professional use.
Post-Procedure Recovery — Microneedling and Laser Aftercare
Supports skin recovery after microneedling, laser, and chemical peels. Deep dermal hydration accelerates fibroblast activation and ECM restoration during the post-procedure healing window.
Advanced Anti-Aging — Dermal Density and Deep Wrinkle Improvement
Core active in next-generation anti-aging targeting dermal density, firmness, and deep wrinkle improvement. Transdermal HA + fibroblast HAS1/HAS2 auto-induction for sustained rejuvenation.
MW Comparison — HA Grades
| Grade | MW | Primary Function | Penetration |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, surface hydration | Surface only |
| Extra Low MW | 100-400 kDa | DEJ-targeted firming, collagen support | Epidermis-dermis junction |
| Super Low MW (this product) | 20-50 kDa | Transdermal delivery, dermal plumping | Dermis |
| Oligo HA | 7-10 kDa | Cellular signaling, wound healing | Deep dermis |
Frequently Asked Questions
Super low MW HA (20-50 kDa) is engineered for transdermal delivery to the dermis. Its hydrodynamic radius (~5-8 nm) enables traversal through the full epidermis and basement membrane into the papillary/reticular dermis — the same tissue compartment targeted by injectable HA fillers. Used in premium plumping serums, needle-free alternatives, lip volumizing, professional treatments, and post-procedure care. The only topical HA grade achieving dermal delivery with meaningful water-binding capacity (~500-1,000×).
Super low MW HA is the closest topical alternative to injectable HA. While it cannot replicate the immediate bulk volume or 6-18 month longevity of crosslinked dermal fillers, its transdermal delivery reaches the dermis — the same target layer — providing visible skin plumping, deep ECM hydration, and fibroblast HAS1/HAS2 activation through non-invasive application. Ideal for needle-free product positioning or complementary at-home maintenance between professional injectable treatments.
Super low MW HA (20-50 kDa) is fundamentally different: High MW stays on surface (film-forming only); Low MW reaches epidermis; Super low MW reaches all the way to the dermis — crossing the basement membrane that excludes larger MW grades (hydrodynamic radius ~5-8 nm vs BM porosity ~10-20 nm effective). Choose this grade when transdermal delivery and deep dermal physical plumping are the formulation goals.
ISO 9001:2015, c-GMP, FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP/EP. Controlled HYAL1 depolymerization yields narrow, reproducible MW distribution (PDI <1.5, GPC-MALLS verified). Full documentation: COA (MW, PDI, purity), MSDS, TSE/BSE, stability data, lot traceability.
0.05-0.2% w/w — effective at very low concentrations due to high dermal bioavailability. Produces low-viscosity solutions ideal for serums and ampoules. For optimal transdermal delivery, pair with penetration enhancers (glycols, liposomes) or formulate at pH 5.0-6.0 to enhance skin permeability.