Sodium Hyaluronate Powder — Low Molecular Weight 400-1,000 kDa Supplier
Sodium Hyaluronate Low Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 400-1,000 kDa) — the deep-penetrating anti-wrinkle HA for serums and anti-aging formulations. With its optimized chain length, low MW HA penetrates beyond the stratum corneum into the deeper epidermis — delivering hydration and active benefits directly where fine lines and wrinkles originate. Unlike high MW HA (1,500-2,000 kDa) which remains on the surface as a protective film, low MW HA replenishes the skin’s natural HA reservoir in the viable epidermis, providing visible wrinkle reduction, improved skin elasticity, and sustained 24-hour deep hydration. Combine with high MW HA (0.1-0.3% each) for comprehensive multi-level hydration: surface film protection + deep anti-aging delivery. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Low MW HA manufacturer and bulk supplier — UPOR Biotech.
Request a QuoteProduct Overview
Sodium Hyaluronate Low Molecular Weight (INCI: Sodium Hyaluronate, CAS 9067-32-7, MW 400-1,000 kDa) is the deep-penetrating grade of HA engineered for anti-aging formulations requiring active ingredient delivery beyond the skin surface. At 400-1,000 kDa, the polymer chains are small enough to navigate the tortuous intercellular lipid pathway of the stratum corneum — penetrating through the compact layers of corneocytes and lipid lamellae into the viable epidermis (stratum granulosum, stratum spinosum, and stratum basale). This is where HA’s biological functions are most impactful: (1) CD44 receptor-mediated signaling in basal keratinocytes stimulates proliferation and differentiation, (2) hydration of the epidermal intercellular matrix maintains optimal desmosome function and desquamation, (3) HA fragments at this MW range (<1,000 kDa) have been shown to stimulate keratinocyte migration and wound healing responses via RHAMM receptor activation. In contrast, high MW HA (1,500-2,000 kDa) is physically excluded from the stratum corneum intercellular spaces (~50-100 nm width — high MW HA hydrodynamic radius ~50-200 nm vs low MW ~20-50 nm) and remains entirely on the surface as a passive hydrating film. This fundamental difference in skin penetration defines the functional roles: low MW HA = active anti-aging ingredient delivering HA to living epidermis; high MW HA = surface film-forming humectant providing immediate but transient hydration. The optimal strategy combines both: low MW HA (0.1-0.3%) for deep anti-wrinkle delivery + high MW HA (0.1-0.3%) for surface film protection — comprehensive multi-level hydration. UPOR Biotech manufactures under c-GMP and ISO 9001:2015 with COSMOS certification and full documentation.
As a specialized HA manufacturer and bulk supplier, UPOR Biotech provides low MW sodium hyaluronate for B2B cosmetic brands, contract manufacturers, and nutraceutical companies. OEM formulations available. Free sample for qualified B2B buyers.
Low MW HA — Deep Hydration Where Wrinkles Form
High MW HA (1,500-2,000 kDa, hydrodynamic radius ~50-200 nm) stays on the skin surface as a protective film — essential for barrier function but physically excluded from the stratum corneum intercellular spaces (~50-100 nm). Low MW HA (400-1,000 kDa, hydrodynamic radius ~20-50 nm) penetrates these intercellular lipid pathways, reaching the lower viable epidermis where fine lines and wrinkles originate. At this depth, it activates CD44-mediated keratinocyte proliferation, RHAMM-mediated migration, and replenishes the epidermal HA reservoir — delivering visible wrinkle reduction and sustained 24-hour hydration. For anti-aging formulations targeting visible results, this deeper delivery is what separates a truly effective serum from a surface moisturizer.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Powder — Low Molecular Weight |
| CAS Number | 9067-32-7 |
| Molecular Weight Range | 400 – 1,000 kDa (GPC-MALLS verified) |
| Key Advantage | Deep epidermal penetration via intercellular lipid pathway (hydrodynamic radius ~20-50 nm vs SC space ~50-100 nm). Anti-wrinkle CD44/RHAMM signaling. Combine with high MW for multi-level hydration. |
| Appearance | White to off-white powder or granules; hygroscopic |
| Purity (HPLC-UV 205 nm) | ≥99.0% |
| pH (0.1% w/v Solution, 25°C) | 6.0 – 7.5 |
| Bulk Density | 0.25 – 0.45 g/mL |
| Solubility | Soluble in water; forms clear solution at 0.1-0.5% w/v (faster hydration than high MW — 1-2 hours) |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals (Total) | ≤10 ppm |
| Microbial Limits | USP <61>/<62> compliant |
| Recommended Usage | 0.1 – 0.5% w/w; 0.2-0.3% optimal for anti-aging; combine with high MW HA 0.1-0.3% for multi-level system |
| Grade | Cosmetic Grade / Food Grade |
| Certifications | ISO 9001:2015, c-GMP, FDA, HALAL, KOSHER, COSMOS, USP/EP |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers with desiccant |
| Storage | 15-25°C; dry, dark place; tightly sealed; shelf life 2-3 years |
Key Benefits — Low MW Sodium Hyaluronate
Deep Epidermal Penetration — Reaches Viable Epidermis
Hydrodynamic radius ~20-50 nm enables passage through SC intercellular lipid spaces (~50-100 nm) that exclude high MW HA (~50-200 nm radius). Delivers HA to the stratum granulosum, spinosum, and basale — where keratinocyte CD44/RHAMM receptors are expressed.
Deep DeliveryVisible Anti-Wrinkle Effect — CD44 and RHAMM Activation
Clinically demonstrated to reduce fine lines and wrinkles. Replenishes the epidermal HA reservoir, activates CD44-mediated keratinocyte proliferation/differentiation and RHAMM-mediated migration, improving skin elasticity and firmness.
Anti-Aging24h Sustained Deep Hydration — Non-Surface Mechanism
Delivers moisture deep within the viable epidermis — not merely surface film hydration. Integrates into the skin’s natural HA network for prolonged 24-hour efficacy that persists after surface films have dissipated.
24h HydrationCertified Quality — Cosmetic and Food Grade
c-GMP (ICH Q7), USP/EP compliant, COSMOS Natural Certified, HALAL, KOSHER. Full documentation: COA, MSDS, TSE/BSE, stability data, lot traceability. Suitable for cosmetic and dietary supplement applications.
c-GMP CertifiedApplications
Anti-Aging Serums — Deep Wrinkle Reduction
Primary active in anti-wrinkle and firming serums at 0.2-0.5%. Deep epidermal delivery enables visible age-reversal effects via CD44/RHAMM keratinocyte activation, not mere surface hydration.
Eye Creams and Treatments — Periocular Anti-Aging
Ideal MW for delicate eye-area formulations at 0.1-0.3%. Penetrates the thinner periocular stratum corneum to reduce crow’s feet and fine lines with non-irritating deep hydration.
Intensive Moisturizers — Multi-Level Hydration Systems
At 0.1-0.3%, combined with high MW HA (0.1-0.3%) for comprehensive multi-level hydration: low MW deep anti-aging + high MW surface protective film. Synergistic dual-MW system.
Neck and Decollete Care — Thin-Skin Targeted Anti-Aging
Penetrates the thinner skin of neck and decollete areas to deliver targeted anti-aging and firming benefits where the epidermis is more permeable and signs of aging are most visible.
Beauty-from-Within Supplements — Oral HA
Food-grade low MW HA for beauty-from-within nutraceuticals. Oral HA supplementation (120 mg/day) shown to increase skin hydration via fibroblast HA synthase upregulation.
Sheet Masks — Extended Contact Deep Delivery
Key active in essence-type sheet masks. The extended 15-20 minute occluded contact time maximizes deep epidermal HA penetration and anti-aging active delivery.
Molecular Weight Comparison — HA Grades
| Grade | MW | Primary Function | Penetration |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, surface hydration | Surface only |
| Medium MW | 1,000-1,500 kDa | Balanced moisturizing, moderate thickening | Upper epidermis |
| Low MW (this product) | 400-1,000 kDa | Deep hydration, anti-wrinkle | Deeper epidermis |
| Extra Low MW | 100-400 kDa | Deep penetration, firming | Epidermis-dermis junction |
| Oligo HA | 7-10 kDa | Cellular signaling, wound healing | Deep dermis |
Frequently Asked Questions
Low MW HA (400-1,000 kDa) is a deep-penetrating anti-wrinkle active for anti-aging serums, eye creams, intensive moisturizers, and sheet masks. Its hydrodynamic radius (~20-50 nm) enables passage through stratum corneum intercellular lipid spaces (~50-100 nm) that exclude high MW HA — delivering HA to the viable epidermis where CD44/RHAMM keratinocyte receptors are expressed. In food applications, used as a dietary supplement for beauty-from-within.
Low MW HA penetrates deeper into the viable epidermis for long-lasting anti-wrinkle hydration via CD44/RHAMM activation. High MW HA (1,500-2,000 kDa) is physically excluded from SC intercellular spaces and stays on the surface as a protective film-forming barrier. For comprehensive results, blend both: high MW for surface protection + low MW for deep anti-aging delivery — a synergistic multi-level hydration strategy.
ISO 9001:2015, c-GMP (ICH Q7), FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP and EP. Every shipment: COA, MSDS, TSE/BSE statement, stability data, complete lot traceability.
0.1-0.5% w/w in cosmetic formulations. At 0.2-0.3%, optimal deep hydration and anti-wrinkle benefits. Hydrates faster than high MW HA (1-2 hours). For multi-level systems: combine 0.1-0.3% low MW HA (deep anti-aging) + 0.1-0.3% high MW HA (surface film protection).
15-25°C in a dry, dark place. Keep containers tightly sealed — HA is hygroscopic. Shelf life 2-3 years under proper storage. Once dissolved in water, use within 24-48 hours or add appropriate preservatives. Avoid high humidity during handling and weighing.