Sodium Hyaluronate Crosspolymer Powder — Cosmetic Grade Supplier
Sodium Hyaluronate Crosspolymer (INCI: Sodium Hyaluronate Crosspolymer, CAS 105524-32-1) — the cross-linked 3D HA molecular sponge. Divinyl sulfone cross-linked into a three-dimensional network that binds ~1,000× its weight in water. Unlike linear HA chains that hydrate quickly but wash away or degrade within hours, the crosslinked structure forms a stable, long-lasting, breathable film delivering up to 5× more moisture retention vs standard HA after 24 hours with superior hyaluronidase resistance. Functions as both an active ingredient (sustained hydration, anti-pollution barrier, TEWL reduction) and a natural-derived texturizer (elegant viscosity, silky after-feel). COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Cosmetic-grade crosspolymer HA manufacturer and bulk supplier — UPOR Biotech.
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Sodium Hyaluronate Crosspolymer (INCI: Sodium Hyaluronate Crosspolymer, CAS 105524-32-1) is a cross-linked, three-dimensional hyaluronic acid derivative engineered through divinyl sulfone (DVS) cross-linking — the same clinically established chemistry used in FDA-approved HA dermal fillers. DVS is a bifunctional vinyl sulfone that reacts with hydroxyl (-OH) groups on adjacent HA chains under alkaline conditions (pH 11-12, NaOH), forming stable sulfonyl-bis-ethyl ether (-O-CH₂-CH₂-SO₂-CH₂-CH₂-O-) crosslinking bridges that connect individual HA polymer chains into a single macroscopic 3D network. Unlike conventional linear sodium hyaluronate — a chain polymer with a defined molecular weight (typically 7-2,500 kDa depending on grade) — crosspolymer HA has no discrete molecular weight: the entire batch is one covalently interconnected macromolecular network with effectively infinite MW. This structural transformation fundamentally changes the material’s behavior: linear HA dissolves in water to form a viscous solution (sol state) that flows, washes away, and is rapidly degraded by skin hyaluronidases (HYAL1/HYAL2) within 4-8 hours. Crosspolymer HA swells but does not dissolve — it forms a cohesive hydrogel that absorbs ~1,000× its weight in water and creates a thin (~1-5 μm), breathable, flexible film on the skin surface that persists for 24+ hours. This film simultaneously: (1) reduces transepidermal water loss (TEWL) via physical occlusion (similar mechanism to petrolatum but breathable — water vapor transmission rate ~80-90% of uncovered skin vs <50% for petrolatum), (2) provides sustained moisture release as the hydrogel film slowly releases bound water to the stratum corneum over 24h (5× more SC moisture at 24h vs linear HA — corneometer data), (3) shields against environmental pollutants (PM2.5 particulate adhesion reduced by 40-60% vs unprotected skin), and (4) resists hyaluronidase degradation — the crosslinked 3D network physically blocks enzyme access to individual HA chain cleavage sites (steric hindrance mechanism), extending functional duration far beyond linear HA. The crosslinked network also provides elegant formulation rheology: at 0.5% w/v, crosspolymer HA produces a clear, transparent gel with viscosity ≥250,000 mPa·s, adding body, slip, and a silky non-tacky after-feel — functioning simultaneously as both an active ingredient and a natural-derived texturizer/sensory enhancer.
As a specialized cosmetic-grade crosspolymer HA manufacturer and bulk supplier, UPOR Biotech provides this advanced 3D HA for premium skincare brands, contract manufacturers, and professional treatment lines. OEM formulations available. Free sample for qualified B2B buyers.
Crosspolymer HA vs Standard Sodium Hyaluronate — What’s Different?
Standard sodium hyaluronate is a linear chain polymer — it dissolves, hydrates quickly, but washes away or is enzymatically degraded within 4-8 hours (HYAL1/HYAL2 cleavage). Crosspolymer HA is a cross-linked 3D macromolecular network — it swells but does not dissolve, forming a stable, breathable film that continuously delivers moisture over 24+ hours and resists hyaluronidase degradation via steric hindrance (enzyme cannot access cleavage sites within the 3D network). Think of it as a single thread (linear HA) vs a knitted fabric (crosspolymer HA): more structure, more durability, 5× more moisture retention at 24h. The crosslinked network also adds elegant viscosity and silky sensory — functioning as both active ingredient and natural texturizer.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Sodium Hyaluronate Crosspolymer Powder — Cosmetic Grade |
| INCI Name | Sodium Hyaluronate Crosspolymer |
| CAS Number | 105524-32-1 |
| Chemical Description | Hyaluronic acid sodium salt, polymer with 1,1′-sulfonylbis[ethene] (divinyl sulfone cross-linked 3D network) |
| Key Advantage | Cross-linked 3D HA: 5× moisture retention vs linear HA at 24h. Breathable film barrier — anti-pollution + TEWL reduction. Hyaluronidase-resistant. Dual-function: active ingredient + natural texturizer. |
| Appearance | White to off-white powder / fibrous particles; hygroscopic |
| Solution Appearance | Clear, transparent gel; A600nm ≤0.01 |
| Light Transmittance (T550nm, 0.5% w/v) | ≥99.0% (exceptional clarity for a crosslinked polymer) |
| Viscosity (0.5% w/v, 25°C) — Critical Quality Attribute | ≥250,000 mPa·s (Brookfield rotational viscometer — confirms crosslinked 3D network formation) |
| pH (0.5% w/v Solution, 25°C) | 5.0 – 8.0 |
| Assay (Sodium Hyaluronate, Dry Basis) | 95.0 – 105.0% (carbazole assay — EP compliant) |
| Water Binding Capacity | ~1,000× its weight in water (equilibrium swelling ratio; 5× higher effective hydration than linear HA) |
| Loss on Drying | ≤15.0% (105°C, 2h) |
| Residue on Ignition | ≤18.0% |
| Protein Content | ≤0.1% |
| Heavy Metals (Total) | ≤10 ppm (as Pb) |
| Bacterial Endotoxins | <0.5 IU/mg (LAL — cosmetic grade) |
| Microbial Limits | TAMC ≤100 CFU/g; TYMC ≤50 CFU/g (USP <61>); Pathogens — Negative (USP <62>) |
| Hyaluronidase Resistance | Significantly enhanced vs linear HA — crosslinked 3D network blocks enzyme access via steric hindrance |
| Film Breathability | Water vapor transmission rate ~80-90% of uncovered skin — breathable occlusion vs petrolatum (<50%) |
| Formulation Compatibility | Compatible with all HA grades (linear, AcHA, cationic); water phase incorporation; gentle stirring avoids shear degradation |
| Recommended Usage | 1-5% w/w typical; range 0.05-10% depending on desired viscosity and film strength |
| Certifications | ISO 9001:2015, c-GMP, FDA Facility Registration, HALAL, KOSHER, COSMOS Natural Certified, USP/EP compliant |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers with desiccant |
| Storage | 2-8°C recommended; tightly sealed; protect from moisture |
| Shelf Life | 3 years under recommended storage; viscosity and clarity re-verified at 3/6/12/24/36 months |
Key Benefits — Crosspolymer HA
5× Longer-Lasting Hydration vs Standard HA at 24h
The cross-linked 3D molecular sponge binds ~1,000× its weight in water and releases it continuously over 24+ hours. Corneometer data shows 5× more SC moisture at 24h vs linear HA — delivering all-day and all-night hydration from a single application.
5× MoistureBreathable Film-Forming Barrier — Anti-Pollution Shield
Creates a thin (~1-5 μm), flexible, breathable film (WVTR 80-90% of uncovered skin) that reduces TEWL while allowing normal skin respiration. Reduces PM2.5 particulate adhesion by 40-60% and shields against UV-induced oxidative stress.
Barrier ShieldHyaluronidase-Resistant — Extended Functional Duration
The crosslinked 3D network physically blocks hyaluronidase access to individual HA chain cleavage sites (steric hindrance). Where linear HA is degraded within 4-8 hours, crosspolymer HA maintains its hydrating film for a full 24h cycle.
Enzyme-ResistantPremium Sensory and Texture — Dual-Function Active + Texturizer
At 0.5% w/v, produces a clear, transparent gel (T550nm ≥99.0%, viscosity ≥250,000 mPa·s) with silky, non-tacky after-feel. Functions as both active ingredient (sustained hydration) and natural-derived texturizer — elegant viscosity without synthetic thickeners.
Sensory EleganceApplications
Long-Lasting Hydrating Serums — 24h Moisture Claims
Star active at 1-5% in premium serums for all-day moisture retention. The sustained-release hydrogel film delivers continuous hydration — ideal for “24h moisture” clinical claim support with corneometer data.
Anti-Aging and Wrinkle Treatments — Visible Smoothing
Core ingredient in eye creams and firming serums. The sustained hydrating film helps plump fine lines and maintain visible smoothing effects throughout the day — physical filling + sustained hydration.
Sleep Masks and Overnight Packs — 8h Continuous Delivery
Perfect for overnight formats where extended wear hydration through the full sleep cycle is critical. Hyaluronidase resistance ensures moisture delivery continues all night without degradation.
Sun Care and Anti-Pollution Day Protection
Protective film against UV, PM2.5, and environmental pollutants while delivering sustained hydration. The breathable barrier (WVTR 80-90%) avoids the heavy, occlusive feel of petrolatum-based protectants.
Color Cosmetics — Primers, BB/CC Creams, Foundations
Adds slip, improves blendability, enhances wear comfort, and provides skin-conditioning benefits. The crosslinked film improves makeup longevity while the hydrogel continuously hydrates the skin underneath.
Professional and Post-Procedure Care — Barrier Protection
Used in post-procedure recovery gels and professional-strength masks where sustained barrier protection and repair hydration are essential. The breathable film protects compromised skin without maceration.
Molecular Weight Comparison — HA Grades
| Grade | MW / Structure | Primary Function | Penetration / Adhesion |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, surface hydration | Surface only |
| Crosspolymer HA (this product) | Cross-linked 3D network (indeterminate MW) | 5× moisture, long-lasting film, anti-pollution, hyaluronidase-resistant, dual active+texturizer | Surface film + sustained release |
| Acetylated HA (AcHA) | ~20-100 kDa + acetyl 23-29% | Amphiphilic, 2× moisture, lipid-anchored, barrier repair | SC lipid-anchored + intra-corneal |
| Cationic HA | >1,000 kDa + cationic -N⁺(CH₃)₃ | Electrostatic adhesion, rinse-resistant, hair cuticle repair | Surface ionic bonding (>80% substantivity) |
| Zinc Hyaluronate | 10-50 kDa + Zn 5-8% | Anti-acne, sebum regulation, wound healing | Epidermis-Dermis |
Frequently Asked Questions
Sodium hyaluronate crosspolymer is a cross-linked 3D HA network created by bonding linear HA chains with divinyl sulfone (-O-CH₂-CH₂-SO₂-CH₂-CH₂-O- bridges). Unlike regular linear HA which dissolves, hydrates quickly, but washes away or is enzymatically degraded within 4-8 hours, crosspolymer HA swells but does not dissolve — forming a molecular sponge that binds ~1,000× its weight in water and creates a stable, breathable film delivering 5× more SC moisture at 24 hours. The crosslinked 3D network also resists hyaluronidase degradation via steric hindrance — enzyme cannot access individual chain cleavage sites within the network — extending functional duration to 24+ hours.
Premium serums (1-5%), anti-aging creams, sleep masks, sunscreens, BB/CC creams, hair care, body lotions. Also excellent as natural texturizer/sensory enhancer replacing synthetic thickeners. Typical usage 1-5% (range 0.05-10% depending on desired viscosity and film strength). Combine with linear HA grades for multi-layer systems: crosspolymer (surface sustained release) + high MW HA (immediate hydration) + low MW HA (deep penetration).
No. Crosspolymer HA has no discrete MW — the entire batch is one covalently interconnected macromolecular 3D network with effectively infinite MW. Evaluate by viscosity (≥250,000 mPa·s at 0.5%), solution clarity (T550nm ≥99.0%), and gel-forming performance instead. The crosslinked structure — not a specific MW number — is what gives its superior water-binding and film-forming properties.
Yes, strongly recommended. Triple-action multi-layer hydration: 1-3% crosspolymer (surface sustained-release film + anti-pollution barrier) + 0.1-0.5% high MW HA (immediate surface hydration) + 0.1-0.5% low/oligo MW HA (deep dermal penetration and cellular signaling). The crosspolymer also helps stabilize and extend the performance of linear HA grades in the formula.
ISO 9001:2015, c-GMP, FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP and EP. Every shipment: COA (viscosity ≥250,000 mPa·s, T550nm ≥99.0%, assay 95.0-105.0%), MSDS, TSE/BSE statement, cross-linking verification data, stability data, complete lot traceability.