Hydrolyzed Sodium Hyaluronate Powder — Enzymatic mini HA 3-5 K Da
Cosmetic & Food Grade. The absolute smallest commercially available HA fragment — approximately 15-25 disaccharide units. Maximum cellular bioactivity, strongest receptor activation, deepest unrestricted penetration. The ultimate HA for regenerative skincare and advanced wound healing. ISO, c-GMP, FDA, HALAL, KOSHER, COSMOS certified.
Request a QuoteProduct Overview
Hydrolyzed Sodium Hyaluronate — Enzymatic mini HA (3-5 K Da) represents the absolute frontier of HA miniaturization. At just 15-25 disaccharide units, this is the smallest commercially available HA fragment in existence. Extended enzymatic hydrolysis using optimized hyaluronidase conditions pushes HA depolymerization to its practical limit while preserving the native glucuronic acid / N-acetylglucosamine dimeric structure.
At 3-5 K Da, HA fragments exhibit maximum receptor-binding potency — the strongest CD44, TLR4, and RHAMM activation of any HA grade. This translates to the most powerful wound healing, angiogenic, and anti-inflammatory signaling achievable with hyaluronic acid. Mini HA is the ultimate ingredient for cutting-edge regenerative skincare, advanced wound dressings, pharmaceutical R&D, and tissue engineering applications.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Hydrolyzed Sodium Hyaluronate (Enzymatic mini HA) |
| CAS Number | 9067-32-7 |
| Molecular Weight | 3 – 5 K Da |
| Production Method | Extended enzymatic hydrolysis (optimized hyaluronidase) |
| Appearance | White to off-white very fine powder |
| Purity (HPLC) | ≥98.0% |
| pH (0.1% solution) | 6.0 – 7.5 |
| Loss on Drying | ≤10.0% |
| Heavy Metals | ≤10 ppm |
| Disaccharide Units | Approximately 15-25 |
| Grade | Cosmetic Grade & Food Grade |
| Certifications | ISO 9001, c-GMP, FDA, HALAL, KOSHER, COSMOS |
| Packaging | 1 kg/bag, 5 kg/bag, 25 kg/drum |
Key Benefits
Maximum Receptor Activation
The strongest CD44/TLR4/RHAMM binding of any HA grade. 3-5 K Da is the optimal size for multi-receptor clustering, producing the most potent cellular signaling response.
Max PotencyUltimate Wound Healing
Clinically validated to accelerate wound closure rates beyond any other HA grade. Stimulates keratinocyte proliferation, fibroblast migration, and collagen synthesis simultaneously.
Rapid HealingComplete Tissue Bioavailability
Diffuses freely through all tissue compartments. No barrier limitation — reaches every skin layer, every cell type. Ideal for transdermal and targeted delivery systems.
100% BioavailablePharmaceutical-Grade Potency
Functions as a biological response modifier at pharmaceutical-level potency. Suitable for advanced drug delivery, tissue engineering scaffolds, and regenerative medicine applications.
Research GradeApplications
Advanced Wound Care
Pharmaceutical wound dressings, burn treatments, and chronic wound management with active biological wound closure.
Tissue Engineering
Scaffold biofunctionalization and cell culture supplements. Supports 3D tissue models and organoid growth.
Regenerative Serums
Maximum-potency regenerative serums for aged, damaged, or compromised skin requiring active biological repair.
Pharma R&D
Drug delivery research, HA-receptor studies, and biomaterial development requiring the smallest defined HA fragments.
FAQ
Mini HA (3-5 K Da) is the smallest commercially available HA fragment — approximately 15-25 disaccharide units. Produced by extended enzymatic hydrolysis, it achieves maximum receptor-binding potency for the strongest wound healing, angiogenic, and anti-inflammatory signaling of any HA grade.
Mini HA is roughly half the molecular weight of Oligo HA (3-5 vs 7-10 K Da). This makes it even more cell-permeable and receptor-active. Mini HA is the most biologically potent HA available, preferred for pharmaceutical and advanced regenerative applications where maximum efficacy at minimum concentration is essential.
0.005-0.05% — the lowest usage rate of any HA grade. At 3-5 K Da, HA functions as a pharmaceutical-grade signaling molecule. Extremely small amounts produce measurable biological responses. Higher concentrations are unnecessary and wasteful.
This product is supplied as Cosmetic & Food Grade. For injectable or implantable applications, please inquire about our EP/DMF/GMP Certified injection-grade sodium hyaluronate series, manufactured under pharmaceutical c-GMP with DMF filing support.