Hydrolyzed Sodium Hyaluronate Powder (Oligo HA) — M.W 7-10 kDa Supplier
Hydrolyzed Sodium Hyaluronate (INCI: Hydrolyzed Sodium Hyaluronate, CAS 9067-32-7, MW 7-10 kDa, ~35-50 disaccharide units) — the smallest, most bioactive HA oligomer. Produced via controlled hyaluronidase enzymatic hydrolysis for precise MW distribution. At this oligomeric size, HA fragments function not as humectants but as potent bioactive cell-signaling molecules — binding CD44 and RHAMM receptors on fibroblasts, keratinocytes, and endothelial cells to activate endogenous repair pathways: proliferation, migration, angiogenesis, and anti-inflammatory cytokine modulation (IL-6/IL-8/TNF-α suppression). Unlike high MW HA which is anti-angiogenic, Oligo HA actively promotes new blood vessel formation and granulation tissue development — uniquely suited for wound care, post-procedure recovery, sensitive skin, and medical cosmetics. COSMOS-certified, ISO 9001:2015, c-GMP, HALAL, KOSHER. Oligo HA manufacturer and bulk supplier — UPOR Biotech.
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Hydrolyzed Sodium Hyaluronate Powder Oligo HA (INCI: Hydrolyzed Sodium Hyaluronate, CAS 9067-32-7, MW 7-10 kDa) is the smallest and most bioactive molecular weight grade of HA — produced through controlled enzymatic hydrolysis using hyaluronidase (HYAL1) which cleaves high MW HA into short oligomeric fragments of ~35-50 disaccharide units (each disaccharide = ~400 Da: D-glucuronic acid β1→3 N-acetyl-D-glucosamine). At 7-10 kDa, HA fragments undergo a fundamental functional transition: polymer grades ≥20 kDa function primarily through physical mechanisms (water-binding, viscosity, film-forming) while oligomeric fragments ≤10 kDa function as bioactive signaling molecules — binding CD44 and RHAMM (CD168) cell-surface receptors with high affinity (Kd ~10-100 nM for oligo-HA-CD44 vs ~μM for high MW HA) and activating intracellular signaling cascades. The key molecular distinction: CD44 exists in multiple isoforms generated by alternative splicing of variant exons (v1-v10). High MW HA (>500 kDa) binds standard CD44H (hematopoietic isoform) and induces receptor clustering → anti-proliferative, anti-angiogenic signaling (maintains tissue homeostasis). Oligomeric HA fragments (6-20 kDa) bind CD44v6 and CD44v9 isoforms — activating pro-proliferative MAPK/ERK and PI3K/Akt pathways, stimulating: (1) fibroblast proliferation and collagen synthesis via CD44v6-ERK1/2 → cyclin D1 upregulation, (2) keratinocyte migration via RHAMM → focal adhesion kinase (FAK) → lamellipodia formation, (3) angiogenesis via CD44v6 on endothelial cells → VEGF receptor 2 (Flk-1/KDR) co-activation → endothelial tube formation (high MW HA inhibits this via CD44H clustering), (4) anti-inflammatory cytokine modulation — suppresses IL-6, IL-8, and TNF-α while upregulating IL-10 (anti-inflammatory) in macrophages and keratinocytes. This opposing size-dependent CD44 signaling is the fundamental bioactive mechanism: high MW HA = homeostasis/maintenance; oligo HA = active repair/regeneration. The controlled HYAL1 enzymatic hydrolysis ensures a narrow, reproducible MW distribution (PDI <1.3, GPC-MALLS verified) — critical because the bioactive functional window is narrow (6-20 kDa): fragments too small (<6 kDa, <15 disaccharide units) lose CD44 binding affinity; fragments too large (>20 kDa) shift toward physical mechanism dominance with reduced receptor-mediated bioactivity. UPOR Biotech manufactures under c-GMP and ISO 9001:2015 with COSMOS certification.
Oligo HA vs Higher MW HA — The Bioactive Cell-Signaling Oligomer
At just 7-10 kDa (~35-50 disaccharide units), Oligo HA is fundamentally different from every other HA grade. Its oligomeric fragments are small enough to bind CD44v6/v9 variant isoforms and RHAMM receptors with nanomolar affinity, activating endogenous repair pathways — MAPK/ERK fibroblast proliferation, FAK keratinocyte migration, VEGF-R2 angiogenesis — that larger HA molecules (>20 kDa) cannot trigger. High MW HA (>500 kDa) binds standard CD44H and signals anti-proliferative/anti-angiogenic homeostasis. Oligo HA produces the opposite response: active repair and regeneration. This transforms HA from a simple humectant into a potent bioactive signaling molecule. For wound care, medical cosmetics, post-procedure recovery, sensitive skin, and next-generation anti-aging beyond surface hydration, Oligo HA delivers cellular-level repair signaling.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Hydrolyzed Sodium Hyaluronate Powder — Oligo HA |
| INCI Name | Hydrolyzed Sodium Hyaluronate |
| CAS Number | 9067-32-7 |
| MW Range | 7 – 10 kDa (~35-50 disaccharide units; GPC-MALLS; PDI <1.3) |
| Key Advantage | Smallest, most bioactive HA — CD44v6/v9 and RHAMM receptor binding (Kd ~10-100 nM). Pro-proliferative, pro-angiogenic, anti-inflammatory signaling. Only HA grade activating repair/regeneration pathways. |
| Production Method | Controlled Enzymatic Hydrolysis (hyaluronidase HYAL1) |
| Degree of Hydrolysis | ≥95% (HPLC-verified) |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥99.0% |
| pH (0.1% w/v) | 6.0 – 7.5 |
| Solubility | Freely soluble; low-viscosity, non-gelling solution |
| Bacterial Endotoxins | ≤0.5 EU/mg (LAL) |
| Loss on Drying | ≤10.0% |
| Protein Content | ≤0.1% |
| Heavy Metals | ≤10 ppm |
| Recommended Usage | 0.01 – 0.1% w/w (effective at trace levels due to high bioactivity) |
| Grade | Cosmetic Grade / Bioactive Grade |
| Certifications | ISO 9001:2015, c-GMP, FDA, HALAL, KOSHER, COSMOS, USP/EP |
| Packaging | 1 kg / 5 kg / 25 kg sealed containers |
| Storage | 15-25°C; cool, dry, dark place; shelf life 24 months |
Key Benefits — Oligo HA
CD44v6/v9 and RHAMR Bioactive Signaling — Repair Activation
Binds CD44 variant isoforms (v6/v9) and RHAMR with nanomolar affinity (Kd ~10-100 nM). Activates MAPK/ERK fibroblast proliferation, FAK keratinocyte migration, and VEGF-R2 angiogenesis — opposite signaling to high MW HA’s anti-proliferative CD44H homeostasis.
BioactiveWound Healing — Granulation and Re-Epithelialization
Pro-angiogenic: stimulates endothelial tube formation (high MW HA is anti-angiogenic). Promotes granulation tissue, keratinocyte migration (lamellipodia via RHAMM-FAK), and collagen synthesis. Clinically validated for wound care and tissue repair.
HealingAnti-Inflammatory — IL-6/IL-8/TNF-α Suppression
Suppresses pro-inflammatory cytokines (IL-6, IL-8, TNF-α) while upregulating IL-10 in macrophages and keratinocytes. Calms post-procedure reactivity and soothes chronic inflammatory conditions — ideal for medical cosmetics.
Anti-InflammatoryPrecise MW Control — HYAL1 Enzymatic Hydrolysis
Controlled hyaluronidase depolymerization produces narrow, reproducible 7-10 kDa distribution (PDI <1.3, GPC-MALLS). Essential because the bioactive window is narrow (6-20 kDa) — consistent receptor activation batch-to-batch.
c-GMP CertifiedApplications
Medical Cosmetics — Post-Procedure Recovery
Bioactive in post-microneedling, laser, and peel serums at 0.02-0.05%. CD44v6-mediated fibroblast activation and anti-inflammatory IL-10 upregulation accelerate post-procedure recovery.
Sensitive Skin Care — Redness and Inflammation
Anti-inflammatory active at 0.01-0.05% for sensitive, reactive, and redness-prone skin. Suppresses IL-6/IL-8/TNF-α while strengthening barrier function via keratinocyte CD44v9 signaling.
Wound Care and Barrier Repair — Pro-Healing Formulations
Pro-angiogenic active at 0.05-0.1% in wound dressings, scar gels, and barrier repair creams. Stimulates granulation tissue, re-epithelialization, and new blood vessel formation — mechanisms high MW HA inhibits.
Bioactive Nutraceuticals — Enhanced Oral Bioavailability
Oligomeric HA (7-10 kDa) with enhanced GI absorption vs higher MW grades. For beauty-from-within and joint health. CD44-mediated intestinal epithelial signaling supports gut barrier integrity.
Dermatological Protocols — Professional-Grade Repair
Clinic-grade active for dermatologist and aesthetician protocols. Professional-strength repair signaling for compromised skin, chronic inflammation, and anti-aging treatment programs.
Anti-Aging Innovation — Beyond Surface Hydration
Deep bioactive at 0.03-0.05% — CD44v6/RHAMR signals fibroblasts to proliferate and maintain collagen/elastin production. Next-generation anti-aging via cellular repair activation, not merely surface film hydration.
MW Comparison — HA Grades
| Grade | MW | Primary Function | Penetration |
|---|---|---|---|
| High MW | 1,500-2,000 kDa | Film-forming, surface hydration (physical) | Surface only |
| Super Low MW | 20-50 kDa | Transdermal delivery, dermal plumping | Dermis |
| Oligo HA (this product) | 7-10 kDa | CD44v6/RHAMR bioactive signaling, wound healing, anti-inflammatory | Deep dermis |
Frequently Asked Questions
Oligo HA (7-10 kDa, ~35-50 disaccharide units) is the smallest, most bioactive HA grade. Unlike higher MW grades functioning as physical film-formers and humectants, Oligo HA acts as a CD44v6/v9 and RHAMR bioactive signaling molecule — binding with nanomolar affinity and activating MAPK/ERK fibroblast proliferation, FAK keratinocyte migration, and VEGF-R2 angiogenesis. High MW HA signals the opposite: anti-proliferative, anti-angiogenic homeostasis. This size-dependent CD44 signaling switch — from homeostasis (high MW) to active repair (oligo) — makes Oligo HA fundamentally distinct.
Oligo HA promotes healing through CD44v6/RHAMR signaling: (1) keratinocyte migration via RHAMR-FAK → lamellipodia formation → wound re-epithelialization, (2) fibroblast proliferation via CD44v6-ERK1/2 → cyclin D1 → collagen/ECM synthesis, (3) angiogenesis via CD44v6-VEGF-R2 co-activation → endothelial tube formation. Unlike high MW HA which is anti-angiogenic, Oligo HA actively stimulates new blood vessel formation — essential for granulation tissue and wound closure.
Yes — exceptionally suited. Low MW penetrates without surface congestion. Anti-inflammatory bioactivity (IL-6/IL-8/TNF-α suppression + IL-10 upregulation) calms redness. CD44v9/RHAMR repair signaling strengthens barrier from within. Ideal for sensitive skin, post-peel/microneedling/laser recovery, and chronic inflammatory conditions. Combine with high MW HA for comprehensive surface protection + deep bioactive repair.
ISO 9001:2015, c-GMP, FDA-registered, HALAL, KOSHER, COSMOS Natural Certified. Meets USP/EP. Controlled HYAL1 enzymatic hydrolysis produces narrow, reproducible MW distribution (PDI <1.3, GPC-MALLS). Full documentation: COA (MW, PDI, purity, endotoxin), MSDS, TSE/BSE, enzyme specification, stability data.
0.01-0.1% w/w — effective at trace levels due to nanomolar CD44/RHAMR receptor affinity (unlike higher MW grades requiring higher concentrations for physical effects). At 0.05%, delivers potent bioactive signaling without viscosity build. Cold-processable, compatible with most cosmetic systems. For wound care/medical devices, optimize based on clinical indication.