Resveratrol Powder — Cosmetic Grade (>=98% HPLC) & Research Grade (>=99%) Supplier
Resveratrol (trans-Resveratrol, CAS 501-36-0) — the most well-characterized natural SIRT1 activator: dual-pathway anti-aging mechanism combining longevity signaling (SIRT1) with the Nrf2/ARE endogenous antioxidant defense network. Plant-derived from Polygonum cuspidatum (Japanese knotweed) root, available as 20-60 mesh granular or fine powder. Clinically validated for wrinkle reduction, collagen preservation, and UV photoprotection — supported by a 2025 double-blind RCT confirming significant anti-aging efficacy at 1.5% topical use. ISO 9001:2015, ISO 22000, FDA, HALAL, KOSHER, Non-GMO certified. Bulk manufacturer and wholesale supplier — premium resveratrol powder from UPOR Biotech.
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Resveratrol (INCI: Resveratrol, trans-Resveratrol, 3,5,4′-Trihydroxystilbene, (E)-5-(4-hydroxystyryl)benzene-1,3-diol, CAS 501-36-0, C14H12O3, MW 228.25 g/mol) is a natural polyphenolic stilbenoid phytoalexin extracted from Polygonum cuspidatum (Japanese knotweed) root that has become one of the most extensively researched anti-aging actives in cosmetic dermatology. Resveratrol operates through a unique dual-pathway mechanism that distinguishes it from single-target antioxidants: (1) SIRT1 activation (longevity pathway) — resveratrol is the most well-characterized natural SIRT1 activator, binding to the enzyme’s N-terminal domain and inducing an allosteric conformational change that increases substrate affinity. Activated SIRT1 deacetylates PGC-1alpha (mitochondrial biogenesis), FOXO transcription factors (stress resistance and DNA repair), and p53 (cellular senescence regulation) — mimicking the molecular effects of calorie restriction and extending cellular lifespan. (2) Nrf2/ARE antioxidant pathway — resveratrol activates the Keap1-Nrf2-ARE signaling axis, dissociating Nrf2 from its cytoplasmic repressor Keap1 and driving nuclear translocation, where Nrf2 binds to Antioxidant Response Elements (ARE) to upregulate phase II detoxification enzymes including heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutathione S-transferase (GST), and endogenous antioxidants glutathione and superoxide dismutase. This dual SIRT1 + Nrf2 mechanism simultaneously activates longevity signaling AND the cell’s intrinsic antioxidant defense network — a combined effect that neither NMN (pure NAD+ precursor) nor pterostilbene (methylated analog with higher oral bioavailability but less cosmetic research) replicates. A landmark 2025 double-blind, placebo-controlled RCT (122 women aged 40+) confirmed that 1.5% topical trans-resveratrol, as the sole active ingredient, significantly reduced wrinkle scores and increased U-zone sebum levels versus placebo, with the oral + topical combination producing the best anti-aging outcomes. UPOR Biotech provides resveratrol in two grades: Cosmetic Grade (>=98% HPLC, 20-60 mesh) optimized for topical formulations, and Research Grade (>=99% HPLC) for high-purity applications.
As a leading resveratrol manufacturer and bulk supplier, UPOR Biotech provides high-purity resveratrol powder for B2B cosmetic brands, contract manufacturers, private-label formulators, and nutraceutical companies worldwide. Resveratrol’s dual SIRT1 + Nrf2 mechanism and extensive clinical validation create premium market positioning — particularly for anti-aging serums, cosmeceutical ampoules, and dermatologist-dispensed skincare lines targeting the growing longevity-beauty segment. OEM and private label formulations available with flexible MOQ starting at 1 kg. Free sample (10-20 g) available for qualified buyers. Every shipment includes full documentation: COA, MSDS, HPLC chromatogram, IR spectrum, botanical source statement, and stability data. ISO 9001:2015, ISO 22000, HACCP, FDA, HALAL, KOSHER, and Non-GMO certified.
Resveratrol vs NMN vs Pterostilbene — The Activator, the Fuel, and the Analog: Why Resveratrol Is the Only Topical Anti-Aging Active with Dual SIRT1 + Nrf2 Pathway Activation
Comparing the three leading longevity molecules reveals complementary — not competitive — mechanisms. NMN (Nicotinamide Mononucleotide) is a direct NAD+ precursor that boosts intracellular NAD+ levels, providing the essential cofactor that sirtuin enzymes require to function. NMN supplies the fuel (NAD+) but does not directly activate sirtuins — it is a metabolic substrate, not a signaling molecule. NMN’s cosmetic use is limited by its high molecular weight, poor topical penetration, and primary applicability to oral supplementation. Pterostilbene is the 3,5-dimethylated analog of resveratrol with 2-4x higher oral bioavailability due to superior lipophilicity, longer half-life, and better blood-brain barrier penetration — but pterostilbene’s cosmetic and topical benefits are far less studied than resveratrol’s, with only ~4 clinical trials versus decades of resveratrol research. Resveratrol is unique among the three: it is the only one with dual SIRT1 activation + Nrf2/ARE antioxidant pathway induction, providing an unmatched breadth of anti-aging signaling. Resveratrol activates longevity signaling (SIRT1), the intrinsic antioxidant defense network (Nrf2), and anti-inflammatory pathways (NF-kB suppression) simultaneously — a triple-target mechanism no other topical active replicates. Resveratrol is also the only one of the three with robust topical clinical data — validated at 1.5% for significant wrinkle reduction in the 2025 double-blind RCT. The optimal anti-aging strategy: resveratrol for topical SIRT1 + Nrf2 activation in skincare, with NMN and/or pterostilbene providing complementary oral NAD+ support and enhanced systemic bioavailability. In cosmetic formulations, resveratrol is the proven choice — it activates the longevity pathway no other topical ingredient addresses, with decades of research and the strongest clinical evidence for wrinkle reduction.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Resveratrol Powder — Cosmetic Grade (>=98% HPLC) / Research Grade (>=99%) |
| INCI Name | Resveratrol |
| Common Name / Synonyms | trans-Resveratrol; 3,5,4′-Trihydroxystilbene; (E)-5-(4-hydroxystyryl)benzene-1,3-diol; trans-3,4′,5-Trihydroxystilbene; 3,4′,5-Stilbenetriol; (E)-Resveratrol |
| CAS Number | 501-36-0 |
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.25 g/mol |
| Source | Polygonum cuspidatum (Japanese knotweed) root extract — natural plant-derived polyphenolic stilbenoid |
| Key Advantage | Dual-pathway anti-aging: SIRT1 activator (longevity pathway) + Nrf2/ARE antioxidant pathway induction. Clinically validated for wrinkle reduction at 1.5% topical use (2025 RCT). Only cosmetic active combining sirtuin activation with endogenous antioxidant defense upregulation. |
| Appearance | White to off-white crystalline powder or granular (20-60 mesh) |
| Assay (Cosmetic Grade) | >=98.0% (HPLC, anhydrous basis) — trans-resveratrol |
| Assay (Research Grade) | >=99.0% (HPLC, anhydrous basis) — trans-resveratrol |
| Identification | IR spectrum conforms to trans-Resveratrol reference standard; HPLC retention time matches trans-Resveratrol RS; UV lambda-max at 306 nm |
| Loss on Drying | <=0.5% (105degC, 2 hours) |
| Residue on Ignition | <=0.1% |
| pH (1% Suspension) | 5.0 – 7.0 |
| Solubility | Soluble in ethanol (~50 mg/mL), DMSO, and organic solvents; slightly soluble in water (~0.03 mg/mL at 25degC). Pre-dissolve in ethanol, 1,3-butanediol, or cosmetic emollient before aqueous phase incorporation. |
| Melting Point | 253 – 255degC |
| Mesh Size / Particle Size | 20-60 mesh granular or fine powder (customizable particle size available upon request) |
| Heavy Metals (Total) | <=10 ppm (as Pb) |
| Elemental Impurities | Pb <=2 ppm; As <=1 ppm; Hg <=1 ppm; Cd <=1 ppm (USP <232> / ICH Q3D compliant) |
| Microbial Limits | TAMC <=100 CFU/g; TYMC <=10 CFU/g (USP <61> / EP <2.6.12>); Pathogens (E. coli, Salmonella, S. aureus, P. aeruginosa) — Absent in 10 g (USP <62> / EP <2.6.13>) |
| Residual Solvents | USP <467> / EP <5.4> / ICH Q3C Class 3 compliant |
| Recommended Usage (Cosmetic) | 0.5 – 1.5%; 1.0% most common for anti-aging efficacy. Pre-dissolve in ethanol or 1,3-butanediol before adding to oil phase or emulsion. Protect from UV light during formulation. |
| Grade / Standards | Cosmetic Grade (>=98% HPLC) / Research Grade (>=99% HPLC available) |
| Certifications | ISO 9001:2015, ISO 22000, HACCP, FDA Facility Registration, HALAL, KOSHER, Non-GMO, BSE/TSE-Free |
| Packaging | 1 kg / 5 kg / 10 kg sealed aluminum foil bags with PE liner; 25 kg fiber drums with double PE liner |
| Storage | 2-8degC, tightly sealed in original container, protect from light and moisture |
| Shelf Life | 2 years from date of manufacture under recommended storage conditions |
Key Benefits — Resveratrol
Dual-Pathway Anti-Aging — SIRT1 Longevity Activation + Nrf2 Antioxidant Defense
Resveratrol’s unique dual mechanism: allosterically activates SIRT1 — the longevity enzyme that deacetylates PGC-1alpha, FOXO, and p53 to extend cellular lifespan — AND activates the Nrf2/ARE pathway to upregulate endogenous antioxidant enzymes (HO-1, NQO1, SOD, glutathione). No other topical active combines sirtuin activation with intrinsic antioxidant defense upregulation.
SIRT1 + Nrf2Clinically Proven Wrinkle Reduction — 2025 Double-Blind RCT Validated at 1.5% Topical
A landmark 2025 RCT (122 women aged 40+) confirmed significant wrinkle reduction with 1.5% trans-resveratrol cream — the first trial using resveratrol as the sole active. Suppresses MMP-mediated collagen degradation via AP-1/NF-kB inhibition AND stimulates collagen synthesis via estrogen receptor (ERbeta) agonism. Decades of research supporting anti-aging efficacy.
Clinically ValidatedCosmetic + Research Dual-Grade — >=98% HPLC with Full Documentation
Cosmetic grade (>=98% HPLC, 20-60 mesh) optimized for topical anti-aging and antioxidant formulations. Research grade (>=99% HPLC) for high-purity applications. Both grades include full documentation — COA, MSDS, HPLC chromatogram, IR spectrum, botanical source statement, and stability data. Free sample available for qualified B2B buyers.
>=98% HPLCNatural Plant-Derived, Non-Toxic — Safe for All Skin Types with ISO-Certified Quality
Resveratrol is a natural polyphenol from Polygonum cuspidatum root — non-cytotoxic, non-irritating, and safe for long-term daily use across all skin types. ISO 9001:2015, ISO 22000, HACCP, FDA, HALAL, KOSHER, and Non-GMO certified with complete lot traceability from raw botanical material to finished product.
Plant-DerivedApplications
Anti-Aging Serums & Night Treatments
Resveratrol at 0.5-1.5% in anti-aging serums and night treatments targeting wrinkle reduction, collagen preservation, and cellular longevity. Pre-dissolve in ethanol or 1,3-butanediol before oil phase incorporation. For optimal stability, use amber packaging and recommend evening application. OEM and private label formulations available.
Premium Cosmeceutical Anti-Aging Ampoules
Cosmetic-grade resveratrol (>=98% HPLC) at 1-1.5% in premium anti-aging ampoules and professional skincare lines. Clinically validated at 1.5% for significant wrinkle reduction per the 2025 double-blind RCT. SIRT1 + Nrf2 dual-pathway positioning for dermatologist-dispensed and longevity-beauty product lines.
Daily Antioxidant Moisturizers & UV Protection
Resveratrol at 0.5-1% in daily moisturizers, sunscreens, and BB/CC creams for comprehensive antioxidant protection. Suppresses UV-induced NF-kB and AP-1 signaling — enhancing photoprotection beyond UV filters alone. Combine with vitamin C and vitamin E for the gold-standard antioxidant triple-defense system.
Eye Contour & Targeted Anti-Wrinkle Treatments
Resveratrol in targeted eye creams, wrinkle-correction serums, and periocular treatments. SIRT1-mediated fibroblast longevity signaling + MMP suppression for the delicate periorbital area. Phytoestrogenic ERbeta agonism provides additional support for menopausal and mature skin in the eye contour zone.
Brightening & Pigmentation Treatments
Resveratrol at 0.5-1% for melanin synthesis reduction via MITF downregulation and tyrosinase inhibition. Combine with niacinamide 4-5% and alpha-arbutin 1% for comprehensive three-pathway brightening — resveratrol adds the SIRT1/Nrf2 anti-aging dimension to traditional brightening formulas.
Post-Procedure Recovery & Barrier Repair
Resveratrol in post-laser, post-peel, and microneedling aftercare formulations. Anti-inflammatory action suppresses COX-2 and iNOS, accelerates barrier recovery, and prevents post-procedure hyperpigmentation. VEGF activation supports angiogenesis and tissue regeneration for faster healing.
Frequently Asked Questions
Resveratrol (CAS 501-36-0, INCI: Resveratrol, C14H12O3, MW 228.25 g/mol) is a natural polyphenolic stilbenoid extracted from Polygonum cuspidatum (Japanese knotweed) root. It operates through a dual-pathway anti-aging mechanism that no other topical active replicates. (1) SIRT1 activation (longevity pathway) — resveratrol is the most well-characterized natural SIRT1 activator, binding to the enzyme’s N-terminal domain and inducing an allosteric conformational change that increases SIRT1’s affinity for its acetylated substrates including PGC-1alpha (mitochondrial biogenesis), FOXO transcription factors (stress resistance and DNA repair), and p53 (cellular senescence regulation). This mimics the molecular effects of calorie restriction, promoting mitochondrial biogenesis, enhancing cellular stress resistance, and extending cellular lifespan. (2) Nrf2/ARE antioxidant pathway — resveratrol activates the Keap1-Nrf2-ARE signaling axis, dissociating Nrf2 from Keap1 and driving nuclear translocation to upregulate phase II detoxification enzymes (HO-1, NQO1, GST) and endogenous antioxidants (glutathione, superoxide dismutase). This dual SIRT1 + Nrf2 mechanism simultaneously activates longevity signaling AND the cell’s intrinsic antioxidant defense network — a combined effect unmatched by single-target antioxidants. Clinically validated at 1.5% topical use for significant wrinkle reduction in a 2025 double-blind RCT. UPOR Biotech provides cosmetic grade (>=98% HPLC, 20-60 mesh) and research grade (>=99%), both from Polygonum cuspidatum with full traceability.
Resveratrol delivers five key benefits for cosmetic formulators and brands: (1) SIRT1-mediated longevity signaling — activates the same cellular pathway as calorie restriction, promoting mitochondrial biogenesis and extending fibroblast lifespan for sustained dermal matrix production. (2) Nrf2/ARE antioxidant defense upregulation — induces endogenous antioxidant enzymes (HO-1, NQO1, SOD, glutathione) providing broad-spectrum protection against UV-induced ROS, pollution, and oxidative stress superior to single-mechanism antioxidants. (3) Collagen preservation and wrinkle reduction — suppresses AP-1 and NF-kB-mediated MMP expression (MMP-1, MMP-3, MMP-9), inhibiting collagen and elastin degradation while stimulating collagen synthesis via ERbeta agonism. A 2025 double-blind RCT (122 women, 8 weeks) confirmed significant wrinkle reduction with 1.5% topical trans-resveratrol as the sole active. (4) Melanin synthesis reduction — inhibits tyrosinase activity and melanogenesis via MITF downregulation, providing brightening benefits complementary to anti-aging action. (5) Anti-inflammatory and barrier repair — suppresses COX-2 and iNOS, calms UV-induced erythema, and accelerates post-procedure recovery via VEGF-mediated angiogenesis. Primary applications: anti-aging serums (0.5-1.5%), cosmeceutical ampoules (1-1.5%), daily antioxidant moisturizers (0.5-1%), eye contour treatments, brightening formulations, and post-procedure recovery products.
Cosmetic usage rate: 0.5-1.5% in leave-on formulations. 1.0% is the most common starting concentration for anti-aging efficacy; 1.5% trans-resveratrol was clinically validated for significant wrinkle reduction in the 2025 RCT. Resveratrol is lipophilic with limited water solubility (~0.03 mg/mL at 25degC) — pre-dissolve in ethanol, 1,3-butanediol, or a suitable cosmetic emollient (caprylic/capric triglyceride, squalane) before incorporating into the oil phase. Avoid prolonged UV exposure during formulation — resveratrol undergoes trans-to-cis photoisomerization under UV; use amber glassware or low-light conditions and package in opaque/amber containers. For enhanced stability and penetration, consider encapsulation (liposomes, nanocarriers) or pairing with synergistic oils such as pomegranate seed oil. Compatible with niacinamide, vitamin C (incorporate in separate phases), vitamin E, peptides, hyaluronic acid, and most cosmetic ingredients. The gold-standard anti-aging combination: Resveratrol 1% + Vitamin C (L-ascorbic acid) 10-15% + Vitamin E (tocopherol) 1% — providing comprehensive SIRT1 activation (resveratrol), direct aqueous-phase radical scavenging (vitamin C), and lipid-phase membrane protection (vitamin E). For optimal results, always formulate with broad-spectrum sunscreen (SPF 30+) — resveratrol enhances photoprotection by suppressing UV-induced NF-kB and AP-1 signaling.
Resveratrol, NMN, and pterostilbene target different nodes in the cellular aging cascade — they are complementary, not competitive. NMN (Nicotinamide Mononucleotide) is a direct NAD+ precursor that boosts intracellular NAD+ levels — the essential cofactor sirtuin enzymes require. NMN provides the fuel (NAD+); it does not directly activate sirtuins. NMN’s high molecular weight and poor topical penetration limit its cosmetic applicability — it is primarily an oral supplement. Pterostilbene is the 3,5-dimethylated analog of resveratrol with 2-4x higher oral bioavailability due to superior lipophilicity — but its cosmetic/topical research is far less extensive than resveratrol’s, with only ~4 clinical trials versus decades of resveratrol data. Pterostilbene does not independently activate Nrf2 to the same degree as resveratrol. Resveratrol is unique — it is the only topical active that combines SIRT1 longevity activation + Nrf2/ARE antioxidant pathway induction, providing a breadth of anti-aging signaling no other single ingredient replicates. Resveratrol has decades of clinical research, excellent safety at cosmetic concentrations, and the strongest topical anti-aging evidence — validated at 1.5% for significant wrinkle reduction in the landmark 2025 RCT. Optimal anti-aging strategy: resveratrol for topical SIRT1 + Nrf2 pathway activation in skincare, with NMN and/or pterostilbene as complementary oral supplements providing systemic NAD+ support. In cosmetic formulations, resveratrol is the proven choice with unparalleled clinical evidence.
Every shipment includes: COA (HPLC purity >=98.0% cosmetic or >=99.0% research, full impurity profile, heavy metals <=10 ppm with Pb <=2 ppm / As <=1 ppm / Hg <=1 ppm / Cd <=1 ppm, residual solvents per USP <467> / EP <5.4> / ICH Q3C, microbial panel per USP <61>/<62> and EP <2.6.12>/<2.6.13>, mesh size analysis 20-60 mesh, loss on drying, residue on ignition, pH, melting point 253-255degC), MSDS, HPLC Chromatogram (signed and dated with trans-resveratrol retention time confirmation), IR Spectrum for identification, BSE/TSE-Free Statement, Non-GMO Statement, Allergen Statement, HALAL Certificate, KOSHER Certificate, ISO 22000 + HACCP, ISO 9001:2015, FDA Facility Registration, Stability Data (2-8degC real-time 24-month and 25degC/60%RH accelerated 6-month), Botanical Source Statement (Polygonum cuspidatum root, China origin, full traceability from raw botanical material to finished product), and Complete Lot Traceability. Free sample (10-20 g) available for qualified B2B buyers. MOQ: 1 kg. All documents provided in English.