Palmitoyl Tripeptide-5 (Syn-Coll) Cosmetic Ingredient Supplier — UPOR Biotech
Palmitoyl Tripeptide-5 (Syn-Coll) — a palmitoylated collagen-stimulating signal peptide that mimics the collagen-inducing domain of thrombospondin-1 to activate TGF-β signaling. Drives the synthesis of collagen types I and III and extracellular matrix proteins for visible firmness, elasticity, and reduced wrinkle depth at low ppm usage. A clean-label, oil-phase-compatible anti-aging serum active — cosmetic-grade bulk supplier, UPOR Biotech.
Request a QuoteProduct Overview
Palmitoyl Tripeptide-5 (CAS 623172-56-5, C₃₃H₆₅N₅O₅, MW 611.9 g/mol) — trade name Syn-Coll — is a palmitoylated signal peptide with the amino acid sequence Palmitoyl-Lys-Val-Lys-OH (Pal-KVK). The C16 palmitoyl group confers lipophilicity, enhancing skin penetration, resistance to enzymatic degradation, and anchoring within the lipid-rich stratum corneum and epidermal layers. Mechanistically, Palmitoyl Tripeptide-5 is a matrikine — a bioactive peptide fragment that mimics the collagen-stimulating domain of thrombospondin-1. By activating TGF-β (transforming growth factor beta) signaling, it stimulates dermal fibroblasts to synthesize collagen type I and type III together with key extracellular matrix proteins such as fibronectin and elastin. The result is measurably improved skin firmness, elasticity, and reduced wrinkle depth — the core of its anti-aging positioning as a cosmetic active.
As a cosmetic-grade anti-aging active, Palmitoyl Tripeptide-5 is positioned for anti-aging and anti-wrinkle serums, creams, and targeted treatments. Its defining formulation advantage is efficacy at low ppm usage rates (typically 1–10 ppm active), enabling high-performance claims with minimal cost-in-use and no impact on color, odor, or viscosity. The peptide is lipophilic and disperses readily into the oil phase of emulsions or in ethanol-based systems, remaining stable across a pH range of 5.0–7.0. As a bulk cosmetic ingredient supplier, UPOR Biotech supplies Palmitoyl Tripeptide-5 (Syn-Coll) with complete documentation under ISO 9001, cGMP, FDA facility registration, HALAL, KOSHER, and COSMOS certifications — supporting clean-label and internationally compliant skincare development.
Palmitoyl Tripeptide-5 (Syn-Coll) vs Palmitoyl Pentapeptide-4 (Matrixyl) — TGF-β Collagen-Stimulating Signal vs KTTKS Matrix Fragment
When comparing Palmitoyl Tripeptide-5 (Syn-Coll) vs Palmitoyl Pentapeptide-4 (Matrixyl), both are palmitoyl signal peptides used as anti-aging actives, but they target different collagen pathways. Syn-Coll (Pal-KVK) is a matrikine that mimics thrombospondin-1 and activates the TGF-β signaling cascade to stimulate collagen type I and III synthesis — prized for firmness and collagen III production. Matrixyl (Pal-KTTKS) is a procollagen C-terminal fragment that stimulates collagen and glycosaminoglycan synthesis via a distinct feedback pathway. For formulators, Syn-Coll is the choice when firmness, collagen III, and TGF-β-mediated anti-wrinkle activity are the primary claims, while Matrixyl emphasizes a broader ECM matrix-building profile. Both are complementary and frequently paired in comprehensive anti-aging systems.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Palmitoyl Tripeptide-5 (Syn-Coll) — Cosmetic Grade Anti-Aging Peptide |
| INCI Name | Palmitoyl Tripeptide-5 |
| Trade Name | Syn-Coll |
| CAS Number | 623172-56-5 |
| Molecular Formula | C₃₃H₆₅N₅O₅ |
| Molecular Weight | 611.9 g/mol |
| Peptide Sequence | Palmitoyl-Lys-Val-Lys-OH (Pal-KVK) |
| Peptide Class | Palmitoyl signal peptide / matrikine |
| Mechanism of Action | TGF-β activation → collagen type I & III synthesis |
| Synthesis Method | Solid-phase peptide synthesis (SPPS) → N-terminal palmitoylation → HPLC purification |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥98.0% |
| Heavy Metals (Total) | ≤10 ppm |
| Lead (Pb) | ≤1 ppm |
| Arsenic (As) | ≤1 ppm |
| Microbial Limits | TPC ≤100 CFU/g; E. coli / Salmonella / S. aureus negative |
| Solubility | Lipophilic — soluble in oil/ethanol; dispersed in emulsion oil phase |
| Sensorial Profile | Neutral — no odor or tint at ppm usage rates; clean, minimalist formulation friendly |
| Recommended Usage Rate | 1 – 10 ppm active |
| pH | 5.0 – 7.0 |
| Grade | Cosmetic Grade |
| Certifications | ISO 9001, cGMP, FDA facility registration, HALAL, KOSHER, COSMOS |
| Packaging | 10 g / 100 g / 1 kg |
| Storage | 2–8°C or -20°C, protected from light and moisture |
| Shelf Life | 2 years |
| Disclaimer | For cosmetic/skincare formulation use |
Key Benefits — Palmitoyl Tripeptide-5 (Syn-Coll)
Stimulates Collagen I & III Synthesis
Activates dermal fibroblasts to upregulate collagen type I and type III production. The collagen III boost is a hallmark of youthful, resilient skin — improving firmness, elasticity, and visibly reducing wrinkle depth.
Collagen I + IIITGF-β / Thrombospondin-1 Matrikine Signaling
Mimics the collagen-stimulating domain of thrombospondin-1, a natural matrikine that activates the TGF-β signaling cascade — the central wound-healing and ECM-remodeling pathway in skin.
TGF-β MatrikinePalmitoyl Lipophilic Form for Skin Penetration
The C16 palmitoyl group confers lipophilicity for enhanced penetration and resistance to enzymatic degradation. Disperses readily into the oil phase of emulsions for stable, high-performance delivery at low ppm.
Lipophilic DeliveryClinically Validated Anti-Wrinkle Peptide
Backed by clinical studies demonstrating measurable wrinkle-depth reduction and skin firming at low ppm usage. A recognized, INCI-listed cosmetic active for anti-aging and anti-wrinkle claims.
Clinically ValidatedApplications
Anti-Aging & Anti-Wrinkle Serums
High-performance serums delivering Palmitoyl Tripeptide-5 at 1–10 ppm for visible wrinkle-depth reduction, firmness, and elasticity. Oil-phase or ethanol-based delivery for maximum penetration and stability.
Skin Firming & Lifting Creams
Rich creams and lifting formulations combining Syn-Coll with humectants and emollients to restore collagen III density and improve facial contours and resilience.
Neck & Décolleté Treatments
Targeted treatments for the neck and décolleté — areas of thin skin with high collagen-turnover demands — formulated to firm, smooth, and reduce crepiness.
Eye Contour Products
Low-ppm Palmitoyl Tripeptide-5 in gentle eye serums and creams to smooth fine lines, firm the periorbital area, and support fragile eye-contour skin without irritation.
Post-Procedure Recovery Formulas
TGF-β-mediated collagen-stimulating actives for post-procedure and recovery skincare, supporting ECM remodeling and skin repair after in-office treatments.
Clean-Label / COSMOS-Compliant Skincare
CO₂-friendly, INCI-listed, and COSMOS-compliant formulations — Palmitoyl Tripeptide-5 supports clean-label, naturally positioned anti-aging skincare with strong sensorial neutrality.
Frequently Asked Questions
Palmitoyl Tripeptide-5 (trade name Syn-Coll) is a palmitoylated signal peptide with the sequence Palmitoyl-Lys-Val-Lys-OH (Pal-KVK). It is a matrikine that mimics the collagen-stimulating domain of thrombospondin-1, activating TGF-β signaling in dermal fibroblasts. This stimulates the synthesis of collagen type I and III and extracellular matrix proteins, improving skin firmness, elasticity, and reducing wrinkle depth.
Both are palmitoyl signal peptides but target different collagen pathways. Palmitoyl Tripeptide-5 (Pal-KVK) mimics thrombospondin-1 and activates the TGF-β signaling cascade to stimulate collagen type I and III synthesis — prized for firmness and collagen III. Palmitoyl Pentapeptide-4 (Pal-KTTKS) is a procollagen C-terminal fragment that stimulates collagen and glycosaminoglycan synthesis via a distinct feedback pathway. They are complementary and frequently paired in comprehensive anti-aging systems.
Palmitoyl Tripeptide-5 is effective at very low ppm usage rates, typically 1–10 ppm active in the final formula. It is lipophilic and disperses readily into the oil phase of emulsions or ethanol-based systems, and remains stable across a pH range of 5.0–7.0. Low usage delivers high-performance anti-aging claims with minimal cost-in-use and no impact on color, odor, or viscosity.
Incorporate Palmitoyl Tripeptide-5 into the oil phase of an emulsion or into ethanol/glycol carrier systems, and avoid extreme pH values outside 5.0–7.0. As a palmitoylated peptide it is inherently stable against enzymatic degradation, but the finished product should be stored protected from light and at controlled temperature to preserve activity.
Every shipment includes a COA (HPLC purity ≥98.0%, peptide sequence confirmation, heavy metals ≤10 ppm, microbial limits), MSDS, HPLC chromatogram, and residual solvent statement. UPOR Biotech supplies Palmitoyl Tripeptide-5 under ISO 9001, cGMP, and FDA facility registration, with COSMOS, HALAL, and KOSHER compliance documentation available to support clean-label and internationally certified skincare development.