Dihydromyricetin (DHM, CAS 27200-12-0, also known as Ampelopsin) is a natural flavanonol — the primary bioactive flavonoid extracted from the leaves of Ampelopsis grossedentata (vine tea / 藤茶), a traditional Chinese medicinal herbal tea consumed for centuries in southern China. DHM is the only known flavonoid that acts as a GABA-A receptor positive allosteric modulator — it binds at the benzodiazepine site of the GABA-A receptor with preference for α4β3δ subunit-containing extrasynaptic receptors, enhancing GABA binding affinity and directly counteracting ethanol's excitatory effects on the central nervous system. This mechanism directly reverses alcohol intoxication: DHM reduces blood alcohol concentration (BAC), accelerates sobriety recovery, and significantly diminishes hangover symptoms including headache, nausea, and cognitive impairment. DHM simultaneously enhances alcohol metabolism by upregulating alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity while inhibiting ethanol-induced CYP2E1 expression — a dual pharmacokinetic/pharmacodynamic mechanism that accelerates ethanol clearance and reduces toxic acetaldehyde accumulation. UPOR Biotech provides DHM standardized to ≥98% by HPLC from Ampelopsis grossedentata leaf extract, with full COA, MSDS, and HPLC chromatogram documentation.

DHM delivers five clinically and mechanistically validated benefits: (1) Hepatoprotective — DHM significantly reduces serum ALT and AST levels, inhibits ethanol-induced CYP2E1 expression, and protects against both alcohol-induced and chemical liver injury through antioxidant and anti-apoptotic mechanisms in hepatocytes. (2) AMPK activation + mTOR inhibition — DHM activates AMP-activated protein kinase (AMPK) and inhibits mechanistic target of rapamycin (mTOR), engaging the same longevity and metabolic health pathways as berberine and resveratrol but binding at distinct allosteric sites, promoting cellular autophagy, mitochondrial biogenesis, and healthy aging. (3) Anti-obesity and metabolic regulation — DHM inhibits adipogenesis via PPARγ downregulation and suppresses lipid accumulation in adipocytes, supporting healthy body weight and metabolic parameters. (4) Potent antioxidant activity — with 8 phenolic hydroxyl (-OH) groups in its flavanonol structure, DHM demonstrates exceptional free radical scavenging capacity with a DPPH IC50 of approximately 6 μg/mL, comparable to quercetin and superior to most common flavonoids. (5) Anti-inflammatory — DHM inhibits both the NF-κB signaling pathway and NLRP3 inflammasome activation, providing dual-pathway anti-inflammatory protection relevant to chronic inflammatory conditions. These five mechanisms make DHM a uniquely versatile nutraceutical active for products targeting alcohol support, liver health, anti-aging, metabolic wellness, and systemic inflammation.

Recommended DHM dosage: 300–600 mg for alcohol support — taken 30–60 minutes before or during alcohol consumption to enhance alcohol metabolism and reduce intoxication severity and hangover symptoms. For general health, antioxidant, and metabolic wellness applications: 100–300 mg daily. UPOR Biotech's DHM is extracted from Ampelopsis grossedentata (vine tea / 藤茶) leaves and standardized to ≥98% Dihydromyricetin by HPLC (Cosmetic/Nutraceutical Grade), with a ≥95% Standard Grade also available for cost-sensitive applications. Each batch is fully characterized by HPLC/UV with λmax at approximately 292 nm, confirming identity and purity against DHM reference standards. The extract is a pale yellow to off-white powder with a defined flavonoid profile dominated by DHM (≥98%), with minor accompanying Ampelopsis flavonoids including myricetin and dihydroquercetin (taxifolin). Full Certificate of Analysis (COA) with signed HPLC chromatogram is provided with every shipment. MOQ: 1 kg. Free sample available for qualified B2B buyers.

DHM, quercetin, resveratrol, and berberine target different and complementary therapeutic axes — they are not interchangeable. Quercetin is a broad-spectrum flavonoid antioxidant with strong radical scavenging (DPPH IC50 ~7 μg/mL) and anti-inflammatory activity via NF-κB inhibition, but lacks GABA-A receptor modulation entirely and has limited oral bioavailability without formulation enhancement — it cannot address alcohol-related applications. Resveratrol is a stilbenoid that activates SIRT1 and AMPK — the canonical longevity pathway — yet provides no alcohol interaction benefit and requires high oral doses (250–500 mg) for clinical effects due to rapid phase II glucuronidation and sulfation. Berberine is an isoquinoline alkaloid (not a flavonoid) with potent AMPK activation and mTOR inhibition for glucose and lipid regulation, but has very poor oral bioavailability (<5%) requiring specialized delivery systems. Dihydromyricetin (DHM) is uniquely positioned as the only flavonoid that combines GABA-A receptor positive allosteric modulation at the benzodiazepine site (directly reversing alcohol intoxication and hangover symptoms via α4β3δ subunit-preferring receptors), AMPK activation + mTOR inhibition (longevity and metabolic pathways via a distinct binding site), and potent antioxidant capacity from 8 phenolic -OH groups (DPPH IC50 ~6 μg/mL) — all in a single natural molecule from vine tea with centuries of safe traditional consumption history. DHM is not a replacement for quercetin, resveratrol, or berberine — it is a complementary multi-target flavonoid that addresses therapeutic gaps the others cannot fill, particularly alcohol-related, GABA-A-mediated, and hangover-reversal applications.

Every shipment of DHM includes comprehensive documentation: COA (HPLC purity ≥98.0%, full impurity profile, heavy metals ≤10 ppm with Pb ≤2 ppm / As ≤1 ppm / Hg ≤1 ppm / Cd ≤1 ppm, residual solvents per ICH Q3C, microbial panel — TAMC ≤1,000 CFU/g, TYMC ≤100 CFU/g, pathogens absent per USP standards), MSDS, HPLC Chromatogram (signed and dated with λmax ~292 nm confirmation), ISO 9001:2015 Certificate, ISO 22000 Certificate, HACCP Certificate, FDA Facility Registration, HALAL Certificate, KOSHER Certificate, Non-GMO Statement, Allergen Statement, BSE/TSE-Free Statement, Stability Data (25°C/60%RH real-time and 40°C/75%RH accelerated), and Complete Lot Traceability from Ampelopsis grossedentata raw leaf material to finished DHM powder. All documentation provided in English. Free sample available for qualified B2B buyers. MOQ: 1 kg. OEM and private label formulations available with flexible specifications.