Biotinoyl Tripeptide-1 (Biotinyl-GHK) Cosmetic Ingredient Supplier — UPOR Biotech
Biotinoyl Tripeptide-1 (Biotinyl-GHK) — a synthetic biotin-conjugated peptide that fuses biotin (vitamin B7) with the Gly-His-Lys (GHK) matrikine tripeptide. It targets the hair-follicle anchoring zone, stimulating collagen IV and laminin 5 synthesis to strengthen anchorage, boost keratinocyte proliferation, and improve scalp microcirculation. The defining hair-growth and anti-hair-loss active for cosmetic-grade hair serums, tonics, and shampoos from UPOR Biotech.
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Biotinoyl Tripeptide-1 (INCI; CAS 299157-54-3, C₂₄H₃₈N₈O₆S, MW 566.67 g/mol) is a synthetic peptide composed of biotin (vitamin B7) conjugated to the matrikine tripeptide Gly-His-Lys (GHK) via the N-terminus. The biotin group aids dermal and hair-follicle delivery while the GHK core provides skin-repair and extracellular-matrix (ECM) signaling. In the hair follicle, Biotinoyl Tripeptide-1 stimulates synthesis of collagen IV and laminin 5 in the anchoring zone, promotes keratinocyte proliferation, improves scalp microcirculation, and reduces follicle miniaturization/atrophy — strengthening hair anchorage to reduce hair loss and support growth. In one ex-vivo study, it increased hair growth 58% and 121% versus control at 2 and 5 ppm respectively.
Cosmetically, Biotinoyl Tripeptide-1 is positioned as a hair-growth serum/tonic active, anti-hair-loss shampoo/conditioner ingredient, and scalp-care peptide, with secondary use in anti-aging skincare through its GHK core. The recommended usage rate is 2 – 5 ppm in the aqueous phase; it is water-soluble and stable at pH 5.0 – 7.0. As a bulk cosmetic ingredient supplier, UPOR Biotech supplies high-purity Biotinoyl Tripeptide-1 (≥98.0% HPLC) with certifications including ISO 9001, cGMP, FDA facility registration, HALAL, KOSHER, and COSMOS.
Biotinoyl Tripeptide-1 vs Tripeptide-1 (GHK) — Biotin Conjugation for Targeted Hair-Follicle Delivery
Both Biotinoyl Tripeptide-1 and Tripeptide-1 (GHK) carry the same Gly-His-Lys matrikine core, but their positioning diverges through biotin conjugation. By attaching biotin (vitamin B7) to the N-terminus, Biotinoyl Tripeptide-1 achieves targeted delivery to the hair follicle and anchors the collagen IV / laminin 5 matrix in the follicle’s anchoring zone — making it the preferred choice for hair-loss, scalp-care, and hair-growth formulations. Tripeptide-1 (GHK), in contrast, is optimized for general skin repair and anti-aging. For formulators, Biotinoyl Tripeptide-1 delivers the same ECM-stimulating GHK activity with a hair-specific delivery advantage, ideal for anti-hair-loss shampoos, tonics, and serums at 2–5 ppm.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Biotinoyl Tripeptide-1 (Biotinyl-GHK) Cosmetic Ingredient |
| INCI Name | Biotinoyl Tripeptide-1 |
| CAS Number | 299157-54-3 |
| Molecular Formula | C₂₄H₃₈N₈O₆S |
| Molecular Weight | 566.67 g/mol |
| Peptide Sequence | Biotinoyl-Gly-His-Lys |
| Active Core | GHK matrikine (Gly-His-Lys) + biotin (vitamin B7) conjugate |
| Product Type | Synthetic biotin-conjugated matrikine peptide |
| Mechanism of Action | Collagen IV / laminin 5 synthesis; keratinocyte proliferation; scalp microcirculation; reduced follicle miniaturization |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥98.0% |
| Heavy Metals (Total) | ≤10 ppm |
| Lead (Pb) | ≤1 ppm |
| Arsenic (As) | ≤1 ppm |
| Microbial Limits | TPC ≤100 CFU/g; pathogens negative |
| Solubility | Water-soluble; added to the aqueous phase |
| Recommended Usage Rate | 2 – 5 ppm |
| pH Range | 5.0 – 7.0 |
| Grade | Cosmetic Grade |
| Certifications | ISO 9001, cGMP, FDA facility registration, HALAL, KOSHER, COSMOS |
| Packaging | 10 g / 100 g / 1 kg |
| Storage | 2–8°C or -20°C, protected from light and moisture |
| Shelf Life | 2 years |
| Disclaimer | For cosmetic and hair-care formulation use |
Key Benefits — Biotinoyl Tripeptide-1
Stimulates Collagen IV & Laminin 5 in Hair Follicles
Activates the GHK matrikine pathway to upregulate collagen IV and laminin 5 in the hair-follicle anchoring zone, reinforcing the basement membrane that holds the hair root firmly in place.
Anchoring MatrixBiotin Conjugation for Targeted Delivery
The biotin (vitamin B7) N-terminal group enhances delivery to the hair follicle and dermis, concentrating GHK activity where hair-follicle repair is needed most.
Targeted DeliveryPromotes Keratinocyte Proliferation & Microcirculation
Stimulates keratinocyte proliferation and improves scalp microcirculation, reviving dormant follicles and supporting a healthier hair-growth environment.
Follicle ActivationAnti-Hair-Loss & Growth Support
Reduces follicle miniaturization/atrophy and strengthens hair anchorage — demonstrated 58% and 121% hair growth vs control at 2 and 5 ppm in an ex-vivo study.
Proven GrowthApplications
Hair Growth Serums & Tonics
Leave-on serums and tonics at 2–5 ppm targeting the anchoring zone to stimulate collagen IV / laminin 5 and reduce hair loss.
Anti-Hair-Loss Shampoos & Conditioners
Rinse-off formulations delivering biotin-conjugated GHK to the follicle for daily scalp and follicle-strengthening support.
Scalp Care & Follicle-Strengthening Treatments
Scalp-care and anti-thinning treatments that improve microcirculation and revive miniaturized follicles.
Eyebrow & Lash Growth Serums
Targeted brow and lash serums leveraging biotin’s delivery advantage to reinforce hair anchorage in delicate follicle zones.
Anti-Aging Skin Care (GHK Core)
Anti-aging serums and creams drawing on the GHK matrikine core for extracellular-matrix signaling and skin repair.
Clean-Label / COSMOS-Compliant Hair Care
COSMOS-compliant and clean-label hair care for brands seeking certified, traceable peptide actives.
Frequently Asked Questions
Biotinoyl Tripeptide-1 (CAS 299157-54-3) is a synthetic biotin-conjugated matrikine peptide combining biotin (vitamin B7) with the Gly-His-Lys (GHK) tripeptide. The biotin group enhances delivery to the hair follicle, while the GHK core stimulates synthesis of collagen IV and laminin 5 in the hair-follicle anchoring zone and promotes keratinocyte proliferation. Together these mechanisms strengthen hair anchorage, improve scalp microcirculation, and reduce follicle miniaturization — supporting hair growth and reducing hair loss.
Both peptides carry the GHK (Gly-His-Lys) matrikine core, but Biotinoyl Tripeptide-1 is conjugated to biotin at the N-terminus. This biotin conjugation improves targeted delivery to the hair follicle and anchors the collagen IV / laminin 5 matrix. Biotinoyl Tripeptide-1 is therefore ideal for hair-loss and scalp-care formulations, while Tripeptide-1 (GHK) is positioned primarily for general skin repair and anti-aging.
The recommended usage rate is 2 – 5 ppm in finished formulations. It is water-soluble and is typically added to the aqueous phase. In one ex-vivo study, hair growth increased 58% and 121% versus control at 2 and 5 ppm respectively.
Biotinoyl Tripeptide-1 is water-soluble and should be incorporated into the aqueous phase, ideally during cooling below 40°C to preserve peptide integrity. It is stable across a pH range of 5.0 – 7.0 and is compatible with hair-care bases — growth serums, tonics, shampoos, and conditioners — as well as anti-aging emulsions.
Every shipment includes: COA (HPLC purity ≥98.0%, full impurity profile), MSDS, HPLC chromatogram, heavy-metals and microbial test reports, and stability data. UPOR Biotech holds ISO 9001, cGMP, FDA facility registration, HALAL, KOSHER, and COSMOS certifications, with complete lot traceability from raw material through final HPLC release.