2,3,5-Trimethylphenol — Key Vitamin E Intermediate, ≥98% GC/HPLC, Chemical Intermediate Grade Supplier
2,3,5-Trimethylphenol (2,3,5-TMP, isopseudocumenol, CAS 697-82-5) — a trimethyl-substituted phenol that serves as the essential aromatic building block for industrial Vitamin E (α-tocopherol) synthesis. The 2,3,5-trimethyl substitution pattern provides the uniquely correct geometry for chromanol ring construction — the bicyclic oxygen heterocycle core of all tocopherols. This positional specificity means no other trimethylphenol isomer can substitute for 2,3,5-TMP in Vitamin E manufacturing. Supplied as a white to pale yellow crystalline solid with ≥98% GC/HPLC purity, mp 92-95°C. ISO 9001:2015 and c-GMP certified. Bulk industrial supply from UPOR Biotech.
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2,3,5-Trimethylphenol (CAS 697-82-5, C₉H₁₂O, MW 136.19 g/mol), also known as isopseudocumenol, 1-hydroxy-2,3,5-trimethylbenzene, and 2,3,5-TMP, is a trimethyl-substituted monohydric phenol — a benzene ring bearing one hydroxyl group and three methyl groups at the 2, 3, and 5 positions. This specific substitution pattern is not arbitrary: it is the precise aromatic core geometry required for industrial Vitamin E (α-tocopherol) chromanol ring construction. In the dominant commercial synthetic route to α-tocopherol, 2,3,5-trimethylphenol undergoes Friedel-Crafts alkylation with isophytol (or phytol) at the 4-position (para to the hydroxyl, the most electronically activated site due to the electron-donating +M effect of the OH group and the +I effects of the three methyl groups), followed by acid-catalyzed intramolecular cyclization between the phenolic hydroxyl and the alkyl side chain to form the dihydropyran ring — generating the characteristic chromanol bicyclic system (a benzene ring fused to a dihydropyran oxygen heterocycle) that is the pharmacophore of all tocopherols. The three methyl groups at positions 2, 3, and 5 on the starting phenol map directly onto positions 5, 7, and 8 of the α-tocopherol chromanol — the exact methylation pattern that distinguishes α-tocopherol (trimethylated, the most biologically active form) from β- (2 methyls), γ- (2 methyls, different positions), and δ-tocopherol (1 methyl). The phenolic hydroxyl group (pKa ~10.6) provides the critical synthetic handle: it can be deprotonated to the phenolate for nucleophilic reactions, alkylated to form ethers, esterified, or participate in the chromanol cyclization itself. Commercially, 2,3,5-TMP is produced by selective methylation of m-cresol (3-methylphenol) or by isomer-selective sulfonation/desulfonation of mixed xylenol streams from coal tar or petroleum refining — with rigorous purification (distillation and/or recrystallization) to achieve ≥98% purity with tight control of isomeric impurities (2,3,6-TMP, 2,4,6-TMP) that would produce incorrect chromanol regioisomers.
From a commercial and industrial perspective, 2,3,5-trimethylphenol occupies a strategic position in the global synthetic Vitamin E supply chain — one of the largest-volume fine chemical intermediates by tonnage. Global Vitamin E production exceeds 25,000 metric tons per year, with the vast majority produced via the 2,3,5-TMP + isophytol synthetic route. This makes 2,3,5-TMP a high-volume, competitively priced chemical intermediate with established, mature manufacturing processes and well-characterized quality parameters. The market is driven by: (1) Animal feed vitamin premixes — the largest end-use segment, where synthetic Vitamin E is an essential micronutrient for poultry, swine, and aquaculture; (2) Human dietary supplements — Vitamin E remains one of the top-selling single-vitamin supplements globally; (3) Food fortification — Vitamin E as an antioxidant and nutrient in processed foods and oils; and (4) Cosmetics and personal care — α-tocopherol and its esters (acetate, succinate) as skin-conditioning antioxidants. Beyond Vitamin E, 2,3,5-TMP derivatives serve as hindered phenolic antioxidants for polymers and lubricants, pharmaceutical intermediates, and agrochemical building blocks — diversifying demand beyond the tocopherol market. UPOR Biotech supplies Industrial Grade, Chemical Intermediate Grade, and Research Grade 2,3,5-trimethylphenol with full quality documentation, ISO 9001:2015 and c-GMP certifications, and dedicated technical support for process optimization and regulatory compliance.
2,3,5-Trimethylphenol — The Irreplaceable Aromatic Core for Vitamin E, Correct 2,3,5-Substitution Pattern, Phenolic Synthetic Handle, Multi-Thousand-Ton Industrial Intermediate
2,3,5-Trimethylphenol is the critical phenolic building block that makes industrial Vitamin E synthesis possible. Its value comes from positional specificity: the three methyl groups at positions 2, 3, and 5 on the phenol ring map with atomic precision onto positions 5, 7, and 8 of the α-tocopherol chromanol — the most biologically active Vitamin E form. No other trimethylphenol isomer (2,4,6-TMP, 2,3,6-TMP, etc.) can produce stereochemically correct α-tocopherol, because their methyl groups would occupy the wrong positions on the final chromanol. This makes 2,3,5-TMP the single irreplaceable aromatic starting material for the dominant synthetic route to Vitamin E — a >25,000 metric ton per year global industry. The chemistry is elegant: 2,3,5-TMP + isophytol → Friedel-Crafts alkylation at the 4-position (para to OH) → acid-catalyzed cyclization → α-tocopherol chromanol. The phenolic hydroxyl is the key functional handle — it activates the ring for electrophilic attack (via its strong +M electron-donating effect), directs the incoming electrophile to the para position, and then participates directly in the intramolecular cyclization that forms the characteristic dihydropyran oxygen heterocycle. The three methyl groups further activate the ring (+I effects) and provide steric protection against unwanted oxidative side reactions at the substituted positions. For Vitamin E manufacturers, 2,3,5-TMP quality directly determines tocopherol quality — isomeric purity (freedom from 2,3,6-TMP and 2,4,6-TMP), assay (≥98% GC/HPLC), and low water content are the critical purchase specifications that ensure clean chromanol formation and high α-tocopherol yield.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | 2,3,5-Trimethylphenol (2,3,5-TMP) — Key Vitamin E Intermediate, Chemical Intermediate Grade |
| Synonyms/Common Names | Isopseudocumenol, 2,3,5-Trimethylphenol, 1-Hydroxy-2,3,5-trimethylbenzene, 2,3,5-TMP, 2,3,5-Trimethyl-1-hydroxybenzene |
| CAS Number | 697-82-5 |
| Molecular Formula | C₉H₁₂O |
| Molecular Weight | 136.19 g/mol |
| Appearance | White to pale yellow crystalline solid — slight yellow discoloration upon prolonged light/air exposure due to slow phenolic oxidation |
| Key Feature/Differentiator | Trimethyl-substituted phenol — the key intermediate in the industrial synthesis of Vitamin E (α-tocopherol) and other antioxidants. The 2,3,5-trimethyl substitution pattern provides the correct aromatic core geometry for chromanol ring construction. No other trimethylphenol isomer can substitute. |
| Melting Point | 92 – 95°C |
| Boiling Point | 230 – 231°C at 760 mmHg |
| Flash Point | ~98°C (closed cup) |
| Density | ~1.02 g/cm³ at 20°C |
| Assay (GC/HPLC) | ≥98.0% (GC-FID area % or HPLC-UV at 220/254/280 nm) |
| Related Substances | Total impurities ≤2.0%; individual unspecified impurity ≤0.5%; isomeric impurities (2,3,6-TMP, 2,4,6-TMP, 2,4,5-TMP) each ≤0.3% — isomeric purity critical for Vitamin E chromanol regiospecificity |
| Water Content (Karl Fischer) | ≤0.5% (typical 0.05–0.20%) |
| Solubility | Slightly soluble in water (~0.5 g/L at 25°C); freely soluble in ethanol, methanol, acetone, ethyl acetate, dichloromethane, chloroform, toluene; soluble in dilute alkaline solutions (phenolate formation, deprotonation of phenolic OH at pH > pKa ~10.6) |
| pH | 5.0 – 7.0 (1% suspension in water at 25°C) — weakly acidic due to phenolic hydroxyl |
| Loss on Drying | ≤1.0% (typical 0.1–0.5%) |
| Ash Content | ≤0.1% (typical 0.02–0.05%) |
| Heavy Metals | Total heavy metals (as Pb) ≤10 ppm; Pb ≤2.0 ppm; As ≤2.0 ppm; Cd ≤1.0 ppm; Hg ≤0.1 ppm |
| Total Plate Count | ≤1,000 CFU/g |
| Yeast & Mold | ≤100 CFU/g |
| E. coli / Salmonella / S. aureus | Negative (absent in 10 g or 25 g sample) |
| Recommended Storage | Cool, dry, well-ventilated area at 15–25°C; tightly sealed containers; protect from light (slight photolability), moisture, heat, and incompatible materials (strong oxidizing agents, strong bases, acid chlorides); avoid dust formation and accumulation |
| Grade | Industrial Grade / Chemical Intermediate Grade / Research Grade |
| Certifications | ISO 9001:2015, c-GMP |
| Packaging | 25 kg net weight in HDPE drum with inner PE liner; 500 kg supersack / FIBC available for bulk orders; custom packaging available upon request |
| Shelf Life | 24 months under recommended storage conditions (retest after 24 months) |
Key Benefits — 2,3,5-Trimethylphenol
Trimethyl Substitution Pattern — the Correct Aromatic Core for Vitamin E Chromanol Ring Construction
The 2,3,5-trimethyl substitution pattern is uniquely correct for α-tocopherol synthesis. The three methyl groups map directly onto positions 5, 7, and 8 of the chromanol ring — the exact trimethylation pattern that defines α-tocopherol (the most biologically active Vitamin E form). This is not interchangeable: 2,4,6-TMP would place methyl groups at the wrong positions, giving an incorrect, biologically inactive chromanol regioisomer. 2,3,6-TMP blocks the ortho position needed for clean Friedel-Crafts alkylation. The 2,3,5 pattern also provides optimal electronic activation — the methyl groups at 2 and 3 donate electron density (+I effect) that, combined with the hydroxyl at 1 (+M effect), powerfully activate the 4-position (para to OH) for the electrophilic alkylation with isophytol. Meanwhile, the 5-methyl group provides steric and electronic balance without blocking key reactive sites. This positional precision — three methyl groups in exactly the right places — is what makes 2,3,5-TMP the irreplaceable starting material for the global synthetic Vitamin E industry.
Correct Aromatic CoreHigh Chemical Purity (≥98%) — Reliable Performance in Multi-Step Industrial Syntheses
Assay ≥98.0% by GC/HPLC ensures consistent, predictable performance in the multi-step Vitamin E synthesis sequence. Industrial α-tocopherol production involves Friedel-Crafts alkylation, cyclization, and often subsequent acetylation or succinylation — each step is sensitive to impurity-driven side reactions. Isomeric purity is critical: even 1-2% of 2,3,6-TMP or 2,4,6-TMP contamination can produce chromanol regioisomers that are difficult to separate from the desired α-tocopherol, reducing yield and requiring additional purification. Low water content (≤0.5%, KF) is essential for Friedel-Crafts alkylation, which employs Lewis acid catalysts (BF₃, AlCl₃, ZnCl₂) that are deactivated by water — moisture in the starting phenol reduces catalyst efficiency and increases catalyst loading costs. Low ash (≤0.1%) prevents catalyst poisoning and residue carryover into the final Vitamin E product. For chemical engineers and process chemists, the batch-to-batch consistency delivered by ≥98% purity 2,3,5-TMP translates directly to predictable yields, reduced rework, and lower cost of goods in high-volume Vitamin E manufacturing.
≥98% PurityPhenolic Hydroxyl Group — Versatile Functional Handle for Etherification, Esterification, and Further Derivatization
The phenolic hydroxyl group (pKa ~10.6) is the central functional handle of 2,3,5-trimethylphenol and the key to its synthetic versatility. In the Vitamin E synthesis itself, the OH plays a dual role: (1) it activates the aromatic ring toward electrophilic substitution — its strong +M (resonance) electron-donating effect increases electron density at the ortho and para positions, with the para position (C-4) being the most accessible and therefore the preferred site for Friedel-Crafts alkylation with isophytol; (2) it participates directly in chromanol ring formation — after alkylation, the phenolic OH attacks the activated carbon of the alkyl side chain in an acid-catalyzed intramolecular cyclization, forming the dihydropyran oxygen heterocycle that defines the chromanol. Beyond Vitamin E, the phenolic OH enables a rich derivatization chemistry: Williamson etherification (alkyl halides, dimethyl sulfate) produces alkyl aryl ethers; esterification (acid chlorides, anhydrides) yields phenolic esters with modified solubility and stability; Mitsunobu reactions provide stereochemical control; and Mannich reactions (formaldehyde + amine) introduce aminomethyl groups at the ortho position, producing benzoxazine and Mannich base derivatives for polymer and pharmaceutical applications. This synthetic flexibility means 2,3,5-TMP is far more than just a Vitamin E precursor — it is a versatile platform chemical for an entire family of trimethyl-substituted aromatic derivatives.
Versatile Functional HandleEstablished Industrial Track Record — Proven Intermediate in Large-Scale Vitamin E Manufacturing
2,3,5-Trimethylphenol has a decades-long, proven track record as the standard industrial intermediate for synthetic Vitamin E. The 2,3,5-TMP + isophytol route to α-tocopherol has been operated at multi-thousand-ton scale by major Vitamin E producers (BASF, DSM, Adisseo, Zhejiang Medicine, NHU) for over 40 years. This means the chemistry, process engineering, quality specifications, and supply chain are thoroughly mature and well-characterized — reducing technical risk for new entrants and ensuring reliable supply. The manufacturing process for 2,3,5-TMP itself is well-established (selective m-cresol methylation or xylenol isomer separation), with multiple independent producers worldwide ensuring competitive pricing and supply security. For Vitamin E manufacturers, this established track record translates to: (1) predictable process performance — the reaction parameters, catalyst loadings, yields, and impurity profiles are well-documented; (2) regulatory acceptance — synthetic Vitamin E from the 2,3,5-TMP route has food/feed additive approvals in all major markets (FDA, EFSA, CFDA); (3) robust supply chain — as a high-volume intermediate, 2,3,5-TMP is produced by multiple qualified manufacturers, reducing single-source dependency; and (4) continuous improvement — decades of industrial optimization have driven purity up, costs down, and environmental footprint minimized. For companies entering or expanding in the synthetic Vitamin E market, 2,3,5-TMP is the lowest-risk, best-characterized starting material.
Proven Track RecordApplications
Vitamin E (α-Tocopherol) Synthesis
The dominant and highest-volume application. 2,3,5-TMP + isophytol → Friedel-Crafts alkylation → acid-catalyzed cyclization → α-tocopherol. The three methyl groups map directly onto positions 5, 7, and 8 of the chromanol. This route produces >25,000 metric tons of synthetic Vitamin E annually for animal feed, human supplements, food fortification, and cosmetics. Tight isomeric purity specifications (<0.3% other TMP isomers) ensure clean chromanol formation and high α-tocopherol yield.
Antioxidant Intermediate
The trimethyl-substituted phenol core is an excellent starting material for hindered phenolic antioxidants used in polymers, lubricants, fuels, and industrial oils. The electron-donating methyl groups stabilize the phenoxyl radical through hyperconjugation, enhancing radical-scavenging activity. Further alkylation at the 4- or 6-position with tert-butyl or other bulky groups produces sterically hindered phenols with exceptional antioxidant performance and thermal stability.
Pharmaceutical Intermediate
The phenolic hydroxyl and electron-rich aromatic ring serve as versatile synthetic handles for constructing more complex pharmaceutical molecules. The methyl substitution pattern provides metabolic stability by blocking CYP450-mediated oxidation at the substituted positions — a valuable property in drug design where oxidative metabolism at aromatic rings is a common clearance mechanism. Used in the synthesis of trimethyl-substituted drug candidates and pharmaceutical building blocks.
Agrochemical Intermediate
2,3,5-TMP is a precursor in the synthesis of certain herbicides, fungicides, and plant growth regulators. The trimethylphenol moiety contributes to target-site binding affinity, environmental stability, and controlled degradation profiles. The phenolic OH provides a convenient functional handle for introducing agrochemically active side chains (ethers, esters, carbamates) while the methyl groups provide lipophilicity for leaf cuticle penetration.
Fragrance & Flavor Intermediate
Derivatization of the phenolic hydroxyl via etherification or esterification yields compounds with smoky, leathery, woody, or phenolic odor profiles used in fine fragrance and flavor formulations. The trimethyl substitution pattern modulates the odor character, vapor pressure, and substantivity of the resulting fragrance materials. Used as a starting material for specialty aroma chemicals.
Polymer & Resin Additive
2,3,5-Trimethylphenol is used as a co-monomer or modifier in phenolic resins, epoxy resins, and engineering plastics. The trimethyl substitution provides thermal stability, increased hydrophobicity, and tuned reactivity (lowered crosslink density compared to phenol itself due to blocked reactive positions). Applications include high-performance coatings, adhesives, and composite materials requiring enhanced thermal and chemical resistance.
Frequently Asked Questions
2,3,5-Trimethylphenol (CAS 697-82-5, C₉H₁₂O, MW 136.19 g/mol), also known as isopseudocumenol or 1-hydroxy-2,3,5-trimethylbenzene, is a trimethyl-substituted phenol that serves as the key aromatic building block in the industrial synthesis of Vitamin E (α-tocopherol). The three methyl groups at positions 2, 3, and 5 of the phenol ring provide the correct substitution pattern that maps directly onto the aromatic core of the chromanol ring system in α-tocopherol. In the dominant industrial route, 2,3,5-trimethylphenol is condensed with isophytol or phytol in a Friedel-Crafts alkylation followed by acid-catalyzed cyclization to form the chromanol ring — the characteristic bicyclic oxygen heterocycle that defines all tocopherols and tocotrienols. The 2,3,5-trimethyl pattern is uniquely correct: the 2-methyl and 3-methyl groups become the methyl substituents on the aromatic portion of the chromanol (positions 7 and 8), while the 5-position methyl maps to position 5 of the chromanol. The 4-position (para to the hydroxyl) remains unsubstituted on the starting phenol — this is the site of electrophilic alkylation by the phytyl side chain. Alternative trimethylphenol isomers (2,4,6- or 2,3,6-) produce chromanol rings with incorrect methyl substitution patterns that do not yield biologically active α-tocopherol. This positional specificity — that only the 2,3,5 isomer maps correctly onto the Vitamin E structure — is what makes 2,3,5-trimethylphenol the irreplaceable starting material for synthetic Vitamin E, a multi-thousand-ton-per-year global industry supporting animal nutrition, human health, and food preservation worldwide.
The six possible trimethylphenol isomers (2,3,4-; 2,3,5-; 2,3,6-; 2,4,5-; 2,4,6-; and 3,4,5-trimethylphenol) differ fundamentally in their methyl group positions around the aromatic ring, and these positional differences produce distinct physical properties, chemical reactivities, and industrial utilities. 2,3,5-Trimethylphenol (mp 92–95°C) has methyl groups at the 2, 3, and 5 positions — this leaves the 4-position (para to OH) and 6-position (ortho to OH, meta to 3-methyl) available for electrophilic substitution. The key distinction for Vitamin E synthesis: only the 2,3,5 isomer positions the methyl groups correctly to map onto the α-tocopherol chromanol structure. 2,4,6-Trimethylphenol (mesitol, mp 70–72°C) has a symmetrical 1,3,5-substitution pattern on the ring — while it is more acidic (pKa ~10.9 vs ~10.6 for 2,3,5-TMP) due to better stabilization of the phenolate anion by the two ortho-methyl groups, its symmetrical methyl arrangement produces the wrong chromanol substitution pattern for Vitamin E, making it unsuitable for α-tocopherol synthesis. It is primarily used as an antioxidant and polymerization inhibitor. 2,3,6-Trimethylphenol (mp 62–64°C) has methyl groups at positions 2, 3, and 6 — this blocks one ortho position (C-6), significantly reducing electrophilic substitution reactivity at that site. It is used in different synthetic applications (dyes, agrochemicals) but does not provide the correct Vitamin E precursor geometry. The melting point trend (2,3,5-TMP: 92–95°C > 2,4,6-TMP: 70–72°C > 2,3,6-TMP: 62–64°C) reflects the decreasing crystal packing efficiency as the methyl pattern becomes less symmetrical. The boiling points also differ (2,3,5-TMP: 230–231°C; 2,4,6-TMP: 220–221°C; 2,3,6-TMP: 226–227°C), enabling isomer separation by fractional distillation during manufacturing. For industrial Vitamin E production, 2,3,5-trimethylphenol is the only trimethylphenol isomer that produces stereochemically correct, biologically active α-tocopherol — there is no substitute isomer. This absolute positional requirement is why isomeric purity (freedom from 2,3,6-TMP and 2,4,6-TMP) is the most critical quality parameter for 2,3,5-TMP purchased for Vitamin E synthesis.
Beyond its primary role as the key Vitamin E intermediate, 2,3,5-trimethylphenol serves as a versatile phenolic building block across multiple chemical industry sectors: (1) Antioxidant Intermediates — the trimethyl-substituted phenol core, with its electron-donating methyl groups activating the ring toward electrophilic substitution and stabilizing the phenoxyl radical through hyperconjugation, makes 2,3,5-TMP an excellent starting material for hindered phenolic antioxidants used in polymers, lubricants, and fuels. Alkylation at the 4- or 6-position with tert-butyl or other bulky groups produces sterically hindered phenols with exceptional radical-scavenging activity comparable to or exceeding BHT (butylated hydroxytoluene). (2) Pharmaceutical Intermediates — the phenolic hydroxyl and the electron-rich aromatic ring serve as synthetic handles for constructing more complex pharmaceutical molecules, including trimethyl-substituted drug candidates where the methyl pattern provides metabolic stability by blocking CYP450-mediated oxidation at the substituted positions. Used in the synthesis of muscle relaxants, anti-inflammatory agents, and cardiovascular drug candidates. (3) Agrochemical Intermediates — 2,3,5-TMP is a precursor in the synthesis of certain herbicides, fungicides, and plant growth regulators where the trimethylphenol moiety contributes to target-site binding, environmental stability, and controlled degradation profiles. The phenolic OH provides a functional handle for introducing carbamate, ether, or ester agrochemical side chains. (4) Fragrance and Flavor Intermediates — derivatization of the phenolic hydroxyl (etherification with alkyl halides, esterification with acid chlorides) yields compounds with smoky, leathery, woody, or phenolic odor profiles used in fine fragrance and flavor formulations. (5) Polymer and Resin Additives — 2,3,5-TMP is used as a co-monomer or modifier in phenolic resins, epoxy resins, and engineering plastics where the trimethyl substitution provides thermal stability, hydrophobicity, and tuned reactivity (fewer reactive sites = lower crosslink density than unsubstituted phenol). (6) Fine Chemical Synthesis — the compound serves as a general synthetic intermediate for trimethyl-substituted aromatic derivatives used across the specialty chemical industry, including dye intermediates, photographic chemicals, and electronic materials precursors.
2,3,5-Trimethylphenol is a phenolic compound that requires standard chemical handling procedures. Storage: Store in a cool, dry, well-ventilated area at 15–25°C in tightly sealed containers. Protect from light, moisture, and incompatible materials (strong oxidizing agents, strong bases, acid chlorides, acid anhydrides). The product is stable under normal storage conditions but may undergo slight discoloration (yellowing) upon prolonged exposure to light and air due to slow oxidative processes at the phenolic hydroxyl — this typically does not affect assay or reactivity but should be minimized by proper container sealing and light-protected storage. Handling: Use appropriate personal protective equipment — nitrile or neoprene gloves, safety goggles, and protective clothing. Work in a well-ventilated area or use local exhaust ventilation. Avoid generating and inhaling dust. The compound has low acute toxicity (oral LD50 rat >2,000 mg/kg) but, like most phenols, is irritating to skin, eyes, and respiratory tract upon direct contact. In case of skin contact, wash thoroughly with soap and water. In case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present. Fire safety: 2,3,5-Trimethylphenol is combustible — flash point ~98°C (closed cup). Keep away from heat, sparks, open flames, and hot surfaces. The dust may form explosive mixtures with air — avoid dust accumulation in processing areas. Firefighting measures: use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Thermal decomposition (above ~250°C) may produce irritating and toxic fumes including carbon monoxide, carbon dioxide, and phenolic vapors. Environmental precautions: Prevent release to the environment — slightly soluble in water (~0.5 g/L at 25°C) but toxic to aquatic organisms (LC50 fish ~10–100 mg/L). Do not discharge into surface waters or sanitary sewers without appropriate treatment. Dispose of waste and containers in accordance with local, regional, and national regulations. A complete Safety Data Sheet (SDS) with full GHS classification, toxicological data, ecological information, disposal considerations, and transport classification is provided with every shipment.
Every shipment of 2,3,5-Trimethylphenol includes a comprehensive documentation package: Certificate of Analysis (COA) with batch-specific GC/HPLC assay (≥98.0%), melting point (92–95°C), boiling point (230–231°C), appearance (white to pale yellow crystalline solid), full related substances profile (individual isomeric impurities — 2,3,6-TMP, 2,4,6-TMP, 2,4,5-TMP — each identified and quantified; total impurities ≤2.0%), water content by Karl Fischer titration (≤0.5%), loss on drying (≤1.0%), ash content (≤0.1%), heavy metals panel (total ≤10 ppm; Pb ≤2.0 ppm; As ≤2.0 ppm; Cd ≤1.0 ppm; Hg ≤0.1 ppm), complete microbial limits (TPC ≤1,000 CFU/g, yeast & mold ≤100 CFU/g, E. coli/Salmonella/S. aureus negative), and residual solvent analysis where applicable; Material Safety Data Sheet (MSDS/SDS) with full GHS classification, safe handling instructions, PPE requirements, first aid measures, firefighting measures, accidental release measures, toxicological data, ecological information, disposal considerations, and transport information; GC or HPLC Chromatogram with full peak annotation and integration; ISO 9001:2015 Certificate (quality management system); c-GMP Compliance Certificate; Non-GMO Statement (product is fully synthetic, no genetically modified organisms involved); Allergen Statement; BSE/TSE-Free Statement; and Complete Lot Traceability — from raw material sourcing through synthesis, purification, quality control testing, and final release. Manufacturing under ISO 9001:2015 quality management and c-GMP guidelines ensures batch-to-batch consistency — a critical requirement for industrial Vitamin E production where variation in 2,3,5-TMP quality directly affects tocopherol yield and purity. All documents are available in English with translations upon request for key markets. Additional documentation — including stability data under various conditions, extended impurity profiling by LC-MS or GC-MS, residual solvent analysis by headspace GC, and regulatory support documentation for food/feed additive dossiers — is available for qualified industrial partners with long-term supply agreements.