7-Chloroquinaldine (7-Chloro-2-methylquinoline, CAS 4965-33-7) is a chlorinated quinoline derivative with the molecular formula C₁₀H₈ClN and molecular weight 177.63 g/mol. The chlorine atom at the 7-position combined with the methyl group at the 2-position creates a uniquely reactive heterocyclic scaffold. It serves as a key building block in pharmaceutical synthesis — particularly for antimalarial drug candidates, kinase inhibitors, and antimicrobial agents. The quinoline core is a privileged pharmacophore present in over 100 FDA-approved drugs, and the 7-chloro substitution pattern is a critical structural motif in several clinical-stage drug candidates including next-generation antimalarials and oncology therapeutics.

Our 7-Chloroquinaldine meets ≥98.0% purity by HPLC with single impurity ≤0.5% and total impurities ≤2.0%. Key specifications include: appearance — white to light yellow crystalline powder; melting point 78-82°C; identification confirmed by IR, ¹H-NMR, and MS; loss on drying ≤0.5%; residue on ignition ≤0.1%; heavy metals ≤10 ppm; residual solvents per USP <467> / ICH Q3C. Each batch includes a comprehensive Certificate of Analysis (COA) with HPLC chromatogram, NMR spectrum, and MS data confirming both purity and structural identity.

Store at 2-8°C in a tightly sealed container protected from light and moisture. Under recommended storage conditions, shelf life is 24 months from the date of manufacture. 7-Chloroquinaldine is stable under normal handling conditions but should be protected from strong oxidizing agents and strong bases. Standard laboratory PPE (gloves, lab coat, eye protection) should be worn when handling. Work in a well-ventilated area or fume hood. For long-term storage beyond 12 months, we recommend sealing under inert gas (nitrogen or argon) and storing at -20°C. Avoid exposure to excessive heat, direct sunlight, and humidity.

7-Chloroquinaldine serves as a versatile synthetic intermediate where the chlorine at the 7-position provides a handle for cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Ullmann-type) to introduce diverse functional groups onto the quinoline core. The 2-methyl group can be oxidized to the corresponding aldehyde or carboxylic acid for further derivatization. Key applications include synthesis of 7-substituted quinoline antimalarials (structurally related to chloroquine and amodiaquine), quinoline-based kinase inhibitors for oncology research, and antimicrobial quinolines targeting DNA gyrase. The ability to selectively functionalize the 7-position while maintaining the quinoline scaffold makes this building block particularly valuable in medicinal chemistry programs focused on lead optimization and SAR studies.

Every shipment includes a comprehensive Certificate of Analysis (COA) with HPLC purity data, IR/NMR/MS spectra confirming identity and structure, and a Material Safety Data Sheet (MSDS). Our manufacturing facilities are ISO 9001:2015 and c-GMP certified, FDA-registered. We provide full lot traceability from raw material sourcing through final QC release. Additional documentation — including residual solvent analysis (GC-HS), elemental analysis, TSE/BSE statement, and ICH stability data — is available upon request. Custom quality control specifications, including GMP-grade qualification with full ICH Q7 validation, can be developed for clinical and commercial programs requiring regulatory submission support.